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Nature Neuroscience Nov 2018Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear...
Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we describe and test the hypothesis that saccades are matched to natural scene statistics and to the receptive field sizes and adaptive properties of neural populations. Specifically, we determined the minimum amplitude of saccades in natural scenes necessary to provide uncorrelated inputs to model neural populations. This analysis predicts the distributions of observed saccade sizes during passive viewing for nonhuman primates, cats, and mice. Furthermore, disrupting the development of receptive field properties by monocular deprivation changed saccade sizes consistent with this hypothesis. Therefore, natural-scene statistics and the neural representation of natural images appear to be critical factors guiding saccadic eye movements.
Topics: Animals; Cats; Mice; Neurons; Photic Stimulation; Primates; Saccades; Visual Fields; Visual Perception
PubMed: 30349110
DOI: 10.1038/s41593-018-0255-5 -
Journal of Motor Behavior 2011Initiation and inhibition of saccadic eye movements has been shown to be impaired in patients with Huntington's disease (HD) and premanifest gene carriers (PMGC), and... (Comparative Study)
Comparative Study
Initiation and inhibition of saccadic eye movements has been shown to be impaired in patients with Huntington's disease (HD) and premanifest gene carriers (PMGC), and may provide biomarkers useful in tracking phenotypic change. Computerized behavioral tests of prosaccade latency and disinhibition presented to 31 non-gene carriers (NGC), 25 PMGC, and 12 HD patients. These tests provided quantitative performance measures without use of eye-tracking equipment. Significant differences on saccade tests were found, with PMGC intermediate between NGC and HD patients. Saccade latency discriminated PMGC from NGC, whereas saccade disinhibition discriminated PMGC from HD patients. Results suggest utility of behavioral saccade measures as premanifest indicators of phenoconversion in HD.
Topics: Adult; Female; Fixation, Ocular; Heterozygote; Humans; Huntington Disease; Inhibition, Psychological; Male; Middle Aged; Photic Stimulation; Psychological Tests; Reaction Time; Saccades; Sensitivity and Specificity
PubMed: 21774606
DOI: 10.1080/00222895.2011.580390 -
Proceedings of the National Academy of... May 2019Both patients with eye movement disorders and healthy participants whose oculomotor range had been experimentally reduced have been reported to show attentional deficits... (Clinical Trial)
Clinical Trial
Both patients with eye movement disorders and healthy participants whose oculomotor range had been experimentally reduced have been reported to show attentional deficits at locations unreachable by their eyes. Whereas previous studies were mainly based on the evaluation of reaction times, we measured visual sensitivity before saccadic eye movements and during fixation at locations either within or beyond participants' oculomotor range. Participants rotated their heads to prevent them from performing large rightward saccades. In this posture, an attentional cue was presented inside or outside their oculomotor range. Participants either made a saccade to the cue or maintained fixation while they discriminated the orientation of a visual noise patch. In contrast to previous reports, we found that the cue attracted visual attention regardless of whether it was presented within or beyond participants' oculomotor range during both fixation and saccade preparation. Moreover, when participants aimed to look to a cue that they could not reach with their eyes, we observed no benefit at their actual saccade endpoint. This demonstrates that spatial attention is not coupled to the executed oculomotor program but instead can be deployed unrestrictedly also toward locations to which no saccade can be executed. Our results are compatible with the view that covert and overt attentional orienting are guided by feedback projections of visual and visuomotor neurons of the gaze control system, irrespective of oculomotor limitations.
Topics: Adult; Attention; Female; Fixation, Ocular; Humans; Male; Orientation; Saccades
PubMed: 31004064
DOI: 10.1073/pnas.1813465116 -
Journal of Vision Apr 2018Does visual processing start anew after each eye movement, or is information integrated across saccades? Here we test a strong prediction of the integration hypothesis:...
Does visual processing start anew after each eye movement, or is information integrated across saccades? Here we test a strong prediction of the integration hypothesis: that information acquired after a saccade interferes with the perception of images acquired before the saccade. We investigate perception of a basic visual feature, grating orientation, and we take advantage of a delayed interference phenomenon-in human participants, the reported orientation of a target grating, briefly presented at an eccentric location, is strongly biased toward the orientation of flanker gratings that are flashed shortly after the target. Crucially, we find that the effect is the same whether or not a saccade is made during the delay interval even though the eye movement produces a large retinotopic separation between target and flankers. However, the trans-saccadic effect nearly vanishes when flankers are displaced to a different screen location even when this location matches the retinotopic coordinates of the target. We conclude that information about grating orientation is integrated across saccades within a spatial region that is defined in external coordinates and thereby is stable in spite of the movement of the eyes.
Topics: Adult; Female; Humans; Male; Orientation; Saccades; Visual Perception; Young Adult
PubMed: 29621386
DOI: 10.1167/18.4.9 -
Journal of Vision Jul 2023We actively seek information from the environment through saccadic eye movements, necessitating continual integration of presaccadic and postsaccadic signals, which are...
We actively seek information from the environment through saccadic eye movements, necessitating continual integration of presaccadic and postsaccadic signals, which are displaced on the retina by each saccade. We tested whether trans-saccadic integration may be related to serial dependence (a measure of how perceptual history influences current perception) by measuring how viewing a presaccadic stimulus affects the perceived orientation of a subsequent test stimulus presented around the time of a saccade. Participants reproduced the position, and orientation of a test stimulus presented around a 16° saccade. The reproduced position was mislocalized toward the saccadic target, agreeing with previous work. The reproduced orientation was attracted toward the prior stimulus and regressed to the mean orientation. These results suggest that both short- and long-term past information affects trans-saccadic perception, most strongly when the test stimulus is presented perisaccadically. This study unites the fields of serial dependence and trans-saccadic perception, leading to potential new insights of how information is transferred and accumulated across saccades.
Topics: Humans; Saccades; Judgment; Photic Stimulation; Retina
PubMed: 37428485
DOI: 10.1167/jov.23.7.7 -
Experimental Brain Research Feb 2015Visual objects briefly presented around the time of saccadic eye movements are perceived compressed towards the saccade target. Here, we investigated perisaccadic...
Visual objects briefly presented around the time of saccadic eye movements are perceived compressed towards the saccade target. Here, we investigated perisaccadic mislocalization with a double-step saccade paradigm, measuring localization of small probe dots briefly flashed at various times around the sequence of the two saccades. At onset of the first saccade, probe dots were mislocalized towards the first and, to a lesser extent, also towards the second saccade target. However, there was very little mislocalization at the onset of the second saccade. When we increased the presentation duration of the saccade targets prior to onset of the saccade sequence, perisaccadic mislocalization did occur at the onset of the second saccade.
Topics: Adult; Analysis of Variance; Female; Humans; Male; Orientation; Perceptual Distortion; Photic Stimulation; Saccades; Space Perception; Time Factors
PubMed: 25370348
DOI: 10.1007/s00221-014-4138-z -
Journal of Vision Nov 2017Saccadic eye movements cause a rapid sweep of the visual image across the retina and bring the saccade's target into high-acuity foveal vision. Even before saccade...
Saccadic eye movements cause a rapid sweep of the visual image across the retina and bring the saccade's target into high-acuity foveal vision. Even before saccade onset, visual processing is selectively prioritized at the saccade target. To determine how this presaccadic attention shift exerts its influence on visual selection, we compare the dynamics of perceptual tuning curves before movement onset at the saccade target and in the opposite hemifield. Participants monitored a 30-Hz sequence of randomly oriented gratings for a target orientation. Combining a reverse correlation technique previously used to study orientation tuning in neurons and general additive mixed modeling, we found that perceptual reports were tuned to the target orientation. The gain of orientation tuning increased markedly within the last 100 ms before saccade onset. In addition, we observed finer orientation tuning right before saccade onset. This increase in gain and tuning occurred at the saccade target location and was not observed at the incongruent location in the opposite hemifield. The present findings suggest, therefore, that presaccadic attention exerts its influence on vision in a spatially and feature-selective manner, enhancing performance and sharpening feature tuning at the future gaze location before the eyes start moving.
Topics: Adult; Attention; Female; Humans; Male; Orientation; Photic Stimulation; Saccades; Visual Perception; Young Adult
PubMed: 29094147
DOI: 10.1167/17.13.2 -
Journal of Neurophysiology Apr 2019The characteristics of movements are strongly history-dependent. Marinovic et al. (Marinovic W, Poh E, de Rugy A, Carroll TJ. eLife 6: e26713, 2017) showed that past...
The characteristics of movements are strongly history-dependent. Marinovic et al. (Marinovic W, Poh E, de Rugy A, Carroll TJ. eLife 6: e26713, 2017) showed that past experience influences the execution of limb movements through a combination of temporally stable processes that are strictly use dependent and dynamically evolving and context-dependent processes that reflect prediction of future actions. Here we tested the basis of history-dependent biases for multiple spatiotemporal features of saccadic eye movements under two preparation time conditions (long and short). Twenty people performed saccades to visual targets. To prompt context-specific expectations of most likely target locations, 1 of 12 potential target locations was specified on ~85% of the trials and each remaining target was presented on ~1% trials. In long preparation trials participants were shown the location of the next target 1 s before its presentation onset, whereas in short preparation trials each target was first specified as the cue to move. Saccade reaction times and direction were biased by recent saccade history but according to distinct spatial tuning profiles. Biases were purely expectation related for saccadic reaction times, which increased linearly as the distance from the repeated target location increased when preparation time was short but were similar to all targets when preparation time was long. By contrast, the directions of saccades were biased toward the repeated target in both preparation time conditions, although to a lesser extent when the target location was precued (long preparation). The results suggest that saccade history affects saccade dynamics via both use- and expectation-dependent mechanisms and that movement history has dissociable effects on reaction time and saccadic direction. NEW & NOTEWORTHY The characteristics of our movements are influenced not only by concurrent sensory inputs but also by how we have moved in the past. For limb movements, history effects involve both use-dependent processes due strictly to movement repetition and processes that reflect prediction of future actions. Here we show that saccade history also affects saccade dynamics via use- and expectation-dependent mechanisms but that movement history has dissociable effects on saccade reaction time and direction.
Topics: Adolescent; Adult; Bias; Cues; Female; Humans; Male; Psychomotor Performance; Reaction Time; Saccades; Task Performance and Analysis
PubMed: 30785812
DOI: 10.1152/jn.00512.2018 -
PloS One 2012Although most instances of object recognition during natural viewing occur in the presence of saccades, the neural correlates of objection recognition have almost...
Although most instances of object recognition during natural viewing occur in the presence of saccades, the neural correlates of objection recognition have almost exclusively been examined during fixation. Recent studies have indicated that there are post-saccadic modulations of neural activity immediately following eye movement landing; however, whether post-saccadic modulations affect relatively late occurring cognitive components such as the P3 has not been explored. The P3 as conventionally measured at fixation is commonly used in brain computer interfaces, hence characterizing the post-saccadic P3 could aid in the development of improved brain computer interfaces that allow for eye movements. In this study, the P3 observed after saccadic landing was compared to the P3 measured at fixation. No significant differences in P3 start time, temporal persistence, or amplitude were found between fixation and saccade trials. Importantly, sensory neural responses canceled in the target minus distracter comparisons used to identify the P3. Our results indicate that relatively late occurring cognitive neural components such as the P3 are likely less sensitive to post saccadic modulations than sensory neural components and other neural activity occurring shortly after eye movement landing. Furthermore, due to the similarity of the fixation and saccade P3, we conclude that the P3 following saccadic landing could possibly be used as a viable signal in brain computer interfaces allowing for eye movements.
Topics: Eye Movements; Female; Fixation, Ocular; Humans; Male; Photic Stimulation; Saccades
PubMed: 23144959
DOI: 10.1371/journal.pone.0048761 -
Journal of Neurophysiology Jan 2017It is generally accepted that the neural circuits that are implicated in saccade control use retinotopically coded target locations. However, several studies have...
UNLABELLED
It is generally accepted that the neural circuits that are implicated in saccade control use retinotopically coded target locations. However, several studies have revealed that nonretinotopic representation is also used. This idea raises a question about whether nonretinotopic coding is egocentric (head or body centered) or allocentric (environment centered). In the current study, we hypothesized that allocentric coding may play a crucial role in immediate saccade control. To test this hypothesis, we used an immediate double-step saccade task toward two sequentially flashed targets with a frame in the background, and we examined whether the end point of the second saccade was affected by a transient shift of the background that participants were told to ignore. When the background was shifted transiently upward (or downward) during the flash of the second target, the second saccade generally erred the target downward (or upward), which was in the direction opposite to the shift of the background. The effect on the second saccade became significant within 150 ms after the frame was presented for decoding and was built up for 200 ms thereafter. When the second saccade was not adjusted, a small, corrective saccade followed within 300 ms. The effect scaled linearly with the shift size up to 3° for a noncorrective second saccade and up to 6° for a corrective saccade. The present results show that an allocentric location of a target is rapidly represented by the brain and used for controlling saccades.
NEW & NOTEWORTHY
We found that the saccade end point was shifted from the actual target position toward the direction expected from allocentric coding when a large frame in the background was transiently shifted during the period of target presentation. The effect occurred within 150 ms. The present study provides direct evidence that the brain rapidly uses allocentric coding of a target to control immediate saccades.
Topics: Female; Fixation, Ocular; Humans; Male; Photic Stimulation; Psychomotor Performance; Reaction Time; Regression Analysis; Saccades; Space Perception; Time Factors; Young Adult
PubMed: 27784804
DOI: 10.1152/jn.00451.2016