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International Journal of Public Health 2023Observational epidemiological studies have shown a link between obesity and sepsis, but any causal relationship is not clear. Our study aimed to explore the correlation...
Observational epidemiological studies have shown a link between obesity and sepsis, but any causal relationship is not clear. Our study aimed to explore the correlation and causal relationship between body mass index and sepsis by a two-sample Mendelian randomization (MR). In large sample genome-wide association studies, single-nucleotide polymorphisms related to body mass index were screened as instrumental variables. Three MR methods, MR-Egger regression, weighted median estimator, and inverse variance-weighted, were used to evaluate the causal relationship between body mass index and sepsis. Odds ratio (OR) and 95% confidence interval (CI) were used as the evaluation index of causality, and sensitivity analyses were conducted to assess pleiotropy and instrument validity. By two-sample MR, the inverse variance weighting method results suggested that increased body mass index was associated with an increased risk of sepsis (odds ratio 1.32; 95% CI 1.21-1.44; = 1.37 × 10) and streptococcal septicemia (OR 1.46; 95% CI 1.11-1.91; = 0.007), but there was no causal relationship with puerperal sepsis (OR, 1.06; 95% CI, 0.87-1.28; = 0.577). Sensitivity analysis was consistent with the results, and there was no heterogeneity and level of pleiotropy. Our study supports a causal relationship between body mass index and sepsis. Proper control of body mass index may prevent sepsis.
Topics: Humans; Genome-Wide Association Study; Body Mass Index; Mendelian Randomization Analysis; Causality; Sepsis
PubMed: 37205044
DOI: 10.3389/ijph.2023.1605548 -
Annals of Surgery May 1956
Topics: Bacteremia; Humans; Sepsis; Shock; Shock, Septic
PubMed: 13314533
DOI: 10.1097/00000658-195605000-00006 -
Journal of Infection in Developing... Nov 2023Ochrobactrum species are emerging Gram-negative, non-fermenting bacteria with low virulence. Infection with the Ochrobactrum species is commonly nosocomial and has been...
Ochrobactrum species are emerging Gram-negative, non-fermenting bacteria with low virulence. Infection with the Ochrobactrum species is commonly nosocomial and has been reported in patients with indwelling medical devices and implants. Among the species of Ochrobactrum infecting humans, Ochrobactrum anthropic and Ochrobactrum intermedium are the commonest ones. We present a case of septicemia caused by Ochrobactrum intermedium in a 75-year-old patient with lower limb cellulitis. This report describes the epidemiology, clinical manifestations, laboratory diagnosis, antibiotic susceptibility pattern, and treatment of Ochrobactrum infections.
Topics: Humans; Aged; Ochrobactrum; Sepsis
PubMed: 38064389
DOI: 10.3855/jidc.17185 -
BMC Pediatrics Jul 2022Many aspects of microbial dissemination appear to vary with host cholesterol levels. Since neonatal septicemia remains a leading cause of newborn admissions and...
BACKGROUND
Many aspects of microbial dissemination appear to vary with host cholesterol levels. Since neonatal septicemia remains a leading cause of newborn admissions and mortality in resource-limited settings, the contribution of abnormal cholesterol levels in maternal and/or newborn blood to the risk of neonatal septicemia and outcome requires elucidation. We aim to determine a relationship between maternal serum and neonatal cord blood cholesterol levels and neonatal septicemia.
METHODS
This will be a mother-newborn pair cohort study. Approximately 353 pregnant women who are eligible and consent to participate in the study will have blood drawn for a lipid profile. Upon delivery, we will analyse the cord blood cholesterol of their newborns and follow them for 28 days to determine whether the infants develop clinical signs and symptoms suggestive of neonatal septicemia. Relative risk will be used to determine the association between cholesterol and newborn septicemia. Poisson regression will be used to estimate the relative risk (with 95% confidence intervals) of developing septicemia.
DISCUSSION
Findings from our study will contribute evidence to support the inclusion of lipid profile screening for pregnant women and newborns. Our study will determine whether newborns with abnormal cholesterol or those born to mothers with abnormal cholesterol will require rigorous follow-up in neonatal clinics.
Topics: Cohort Studies; Female; Humans; Infant; Infant, Newborn; Lipids; Mothers; Neonatal Sepsis; Pregnancy; Sepsis; Uganda
PubMed: 35858938
DOI: 10.1186/s12887-022-03494-w -
British Journal of Anaesthesia Jan 1976
Review
Topics: Anesthesia; Anti-Bacterial Agents; Disseminated Intravascular Coagulation; Humans; Infusions, Parenteral; Kidney Diseases; Lung Diseases; Sepsis; Shock
PubMed: 766795
DOI: 10.1093/bja/48.1.41 -
Medicine Jul 2020The ability of sepsis to induce acute phase hearing impairment has been evaluated in septic and sepsis-surviving mice. The relationship between septicemia and long-term...
The ability of sepsis to induce acute phase hearing impairment has been evaluated in septic and sepsis-surviving mice. The relationship between septicemia and long-term hearing impairment remains unknown in humans.The data were obtained from the Taiwan Longitudinal National Health Insurance Database from 2000 to 2013. We identified patients suffering from septicemia after discharge, excluding those younger than 18 years old and older than 65 years old. The comparison group was matched based on age, sex, and comorbidities. The outcome was hearing impairment occurring after septicemia. The risk factors associated with hearing impairment were established using multivariate Cox proportional hazard regression.Our study found that septicemia associated with hearing impairment had an adjusted hazard ratio (HR) of 53.11 (95% confidence interval [CI]: 41.74-67.59). The other factors related to hearing impairment in young and middle-aged septicemia survivors included male sex (adjusted HR 1.31 [95% CI: 1.14-1.5]), chronic kidney disease (adjusted HR 1.63 [95% CI: 1.38-1.94]), and otoscleroisis (adjusted HR 231.54 [95% CI: 31.61-1695.8]).Our study revealed that septicemia was associated with increased development of hearing impairment in young and middle-aged humans in the long term. Clinicians should be aware of long-term septicemia-related hearing impairment and provide prevention strategies for otopathy in septicemia survivors.
Topics: Adolescent; Adult; Comorbidity; Female; Humans; Male; Middle Aged; Persons With Hearing Impairments; Proportional Hazards Models; Risk Factors; Sepsis; Survivors; Taiwan
PubMed: 32702847
DOI: 10.1097/MD.0000000000021050 -
The Korean Journal of Internal Medicine Nov 2018Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming... (Review)
Review
Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming primary septicemia caused by consuming contaminated seafood, wound infections acquired when an open wound is exposed to contaminated warm seawater, and gastrointestinal tract-limited infections. Case-fatality rates are higher than 50% for primary septicemia, and death typically occurs within 72 hours of hospitalization. Risk factors for V. vulnificus infection include chronic liver disease, alcoholism, and hematological disorders. When V. vulnificus infection is suspected, appropriate antibiotic treatment and surgical interventions should be performed immediately. Third-generation cephalosporin with doxycycline, or quinolone with or without third-generation cephalosporin, may be potential treatment options for patients with V. vulnificus infection.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Female; Food Microbiology; Foodborne Diseases; Humans; Male; Middle Aged; Public Health; Risk Factors; Seafood; Seawater; Sepsis; Surgical Wound Infection; Treatment Outcome; Vibrio Infections; Vibrio vulnificus; Young Adult
PubMed: 29898575
DOI: 10.3904/kjim.2018.159 -
Indian Journal of Medical Microbiology 2013Streptococcus pasteurianus is part of the normal flora of the intestine. It has also been isolated from various infection sites. However, to date it has not been...
Streptococcus pasteurianus is part of the normal flora of the intestine. It has also been isolated from various infection sites. However, to date it has not been reported as a cause of fulminant septicemia and death. We report the post-mortem findings in a splenectomized hemophiliac patient with cirrhosis and concurrent human immunodeficiency virus (HIV), hepatitis B and hepatitis C infections.
Topics: Fatal Outcome; HIV Infections; Hemophilia A; Hepatitis B; Hepatitis C; Humans; Male; Middle Aged; Sepsis; Splenectomy; Streptococcal Infections; Streptococcus
PubMed: 23883726
DOI: 10.4103/0255-0857.115668 -
British Medical Journal May 1980
Topics: Anti-Bacterial Agents; Humans; Pseudomonas Infections; Sepsis
PubMed: 7388486
DOI: No ID Found -
British Medical Journal Oct 1979
Topics: Child; Humans; Infant; Meningococcal Infections; Penicillin G; Sepsis
PubMed: 509172
DOI: No ID Found