-
Brazilian Journal of Microbiology :... Mar 2021We herein present a Brazilian guideline for the management of feline sporotrichosis, a mycosis caused by Sporothrix brasiliensis. This guideline is an effort of a... (Review)
Review
We herein present a Brazilian guideline for the management of feline sporotrichosis, a mycosis caused by Sporothrix brasiliensis. This guideline is an effort of a national technical group organized by the Working Group on Sporothrix and Sporotrichosis of the International Society for Human and Animal Mycology (ISHAM). This publication intends to provide information on clinical-epidemiological aspects of this zoonosis, as well as a literature revision. Moreover, it gives some practical information on diagnosis and treatment of feline sporotrichosis. It also contains information that can be helpful for the prevention and control of S. brasiliensis transmission.
Topics: Animals; Antifungal Agents; Brazil; Cat Diseases; Cats; Guidelines as Topic; Sporothrix; Sporotrichosis
PubMed: 32990922
DOI: 10.1007/s42770-020-00365-3 -
The New England Journal of Medicine Feb 2019
Topics: Aged; Humans; Male; Skin; Sporothrix; Sporotrichosis
PubMed: 30786190
DOI: 10.1056/NEJMicm1809179 -
Journal of Fungi (Basel, Switzerland) Jul 2022Sporotrichosis, a human and animal disease caused by species, is the most important implantation mycosis worldwide. taxonomy has improved in recent years, allowing... (Review)
Review
Sporotrichosis, a human and animal disease caused by species, is the most important implantation mycosis worldwide. taxonomy has improved in recent years, allowing important advances in diagnosis, epidemiology, and treatment. Molecular epidemiology reveals that remains highly prevalent during the cat-transmitted sporotrichosis outbreaks in South America and that the spread of occurs through founder effects. and are cosmopolitan on the move, causing major sapronoses in Asia and the Americas, respectively. In this emerging scenario, one-health approaches are required to develop a creative, effective, and sustainable response to tackle the spread of sporotrichosis. In the 21st century, it has become vital to speciate , and PCR is the main pillar of molecular diagnosis, aiming at the detection of the pathogen DNA from clinical samples through multiplex assays, whose sensitivity reaches remarkably three copies of the target. The treatment of sporotrichosis can be challenging, especially after the emergence of resistance to azoles and polyenes. Alternative drugs arising from discoveries or repositioning have entered the radar of basic research over the last decade and point to several molecules with antifungal potential, especially the hydrazone derivatives with great in vitro and in vivo activities. There are many promising developments for the near future, and in this review, we discuss how these trends can be applied to the -sporotrichosis system to mitigate the advance of an emerging and re-emerging disease.
PubMed: 35893145
DOI: 10.3390/jof8080776 -
Journal of Fungi (Basel, Switzerland) Aug 2022Sporotrichosis is a chronic fungal disease of humans and other mammals that often affects the skin and subcutaneous tissues and, rarely, deep-seated organs (most...
Sporotrichosis is a chronic fungal disease of humans and other mammals that often affects the skin and subcutaneous tissues and, rarely, deep-seated organs (most frequently in immunocompetent hosts) [...].
PubMed: 36012809
DOI: 10.3390/jof8080821 -
Brazilian Journal of Microbiology :... Mar 2021Sporotrichosis is an endemic mycosis caused by the species of the Sporothrix genus, and it is considered one of the most frequent subcutaneous mycoses in Mexico. This...
Sporotrichosis is an endemic mycosis caused by the species of the Sporothrix genus, and it is considered one of the most frequent subcutaneous mycoses in Mexico. This mycosis has become a relevant fungal infection in the last two decades. Today, much is known of its epidemiology and distribution, and its taxonomy has undergone revisions. New clinical species have been identified and classified through molecular tools, and they now include Sporothrix schenckii sensu stricto, Sporothrix brasiliensis, Sporothrix globosa, and Sporothrix luriei. In this article, we present a systematic review of sporotrichosis in Mexico that analyzes its epidemiology, geographic distribution, and diagnosis. The results show that the most common clinical presentation of sporotrichosis in Mexico is the lymphocutaneous form, with a higher incidence in the 0-15 age range, mainly in males, and for which trauma with plants is the most frequent source of infection. In Mexico, the laboratory diagnosis of sporotrichosis is mainly carried out using conventional methods, but in recent years, several researchers have used molecular methods to identify the Sporothrix species. The treatment of choice depends mainly on the clinical form of the disease, the host's immunological status, and the species of Sporothrix involved. Despite the significance of this mycosis in Mexico, public information about sporotrichosis is scarce, and it is not considered reportable according to Mexico's epidemiological national system, the "Sistema Nacional de Vigilancia Epidemiológica." Due to the lack of data in Mexico regarding the epidemiology of this disease, we present a systematic review of sporotrichosis in Mexico, between 1914 and 2019, that analyzes its epidemiology, geographic distribution, and diagnosis.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Male; Mexico; Middle Aged; Sporothrix; Sporotrichosis; Young Adult
PubMed: 33125684
DOI: 10.1007/s42770-020-00387-x -
Journal of Fungi (Basel, Switzerland) Oct 2018Sporotrichosis is a neglected, deep-seated fungal infection traditionally associated with Sporothrixschenckii, a dimorphic organism that was first described more than a...
Sporotrichosis is a neglected, deep-seated fungal infection traditionally associated with Sporothrixschenckii, a dimorphic organism that was first described more than a century ago in human andrat specimens [1].[...].
PubMed: 30321990
DOI: 10.3390/jof4040116 -
Brazilian Journal of Microbiology :... Mar 2021Sporothrix schenckii sensu lato is currently recognized as a species complex with only Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa... (Review)
Review
Sporothrix schenckii sensu lato is currently recognized as a species complex with only Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa and Sporothrix pallida identified to cause disease in the cat. Feline sporotrichosis in Asia is mainly reported from Malaysia where a single clonal strain of clinical clade D, Sporothrix schenckii sensu stricto manifesting low susceptibility to major antifungal classes, has been identified as the agent of the disease. Sporothrix globosa has been identified to cause disease from a single cat in Japan while the specific species of agent has not been identified yet for the disease in Thailand. Despite efforts to elucidate and describe the pathogenicity of the agent and the disease it causes, the paucity of data highlights the need for further molecular epidemiological studies to characterize this fungus and the disease it causes in Asia. Its prognosis remains guarded to poor due to issues pertaining to cost, protracted treatment course, zoonotic potential and low susceptibility of some strains to antifungals.
Topics: Animals; Antifungal Agents; Asia; Cat Diseases; Cats; Sporothrix; Sporotrichosis
PubMed: 32363567
DOI: 10.1007/s42770-020-00274-5 -
The American Journal of Tropical... Jan 2022
Topics: Antifungal Agents; Humans; Sporothrix; Sporotrichosis
PubMed: 35073510
DOI: 10.4269/ajtmh.21-1212 -
Infection and Drug Resistance 2022Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. , and are the main etiological agents of this... (Review)
Review
Sporotrichosis is an important subcutaneous mycosis with high prevalence and threat to human and animal health worldwide. , and are the main etiological agents of this disease; and even though many efforts have been made recently to understand the -host interaction, little is known about , an underestimated species. This organism shows the lowest virulence among the members of the pathogenic clade and represents an important pathogenic agent due to its global distribution. Here, we offer a review with all the known information about , including its genome and proteomic information, and compare it with and , to explain the differences observed among these species, in terms of virulence, the host immune response, and the antifungal sensitivity. Also, we provide the gene prediction of some putative virulence factors.
PubMed: 35498634
DOI: 10.2147/IDR.S362099 -
Clinical Microbiology Reviews Oct 2011Sporotrichosis, which is caused by the dimorphic fungus Sporothrix schenckii, is currently distributed throughout the world, especially in tropical and subtropical... (Review)
Review
Sporotrichosis, which is caused by the dimorphic fungus Sporothrix schenckii, is currently distributed throughout the world, especially in tropical and subtropical zones. Infection generally occurs by traumatic inoculation of soil, plants, and organic matter contaminated with the fungus. Certain leisure and occupational activities, such as floriculture, agriculture, mining, and wood exploitation, are traditionally associated with the mycosis. Zoonotic transmission has been described in isolated cases or in small outbreaks. Since the end of the 1990s there has been an epidemic of sporotrichosis associated with transmission by cats in Rio de Janeiro, Brazil. More than 2,000 human cases and 3,000 animal cases have been reported. In humans, the lesions are usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. In cats, the disease can evolve with severe clinical manifestations and frequent systemic involvement. The gold standard for sporotrichosis diagnosis is culture. However, serological, histopathological, and molecular approaches have been recently adopted as auxiliary tools for the diagnosis of this mycotic infection. The first-choice treatment for both humans and cats is itraconazole.
Topics: Animals; Cats; Humans; Sporothrix; Sporotrichosis
PubMed: 21976602
DOI: 10.1128/CMR.00007-11