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Biomedicine & Pharmacotherapy =... Oct 2022In recent years, increasing attention has been paid to the pharmacological efficacy of tannins. Tannic acid (TA), the simplest hydrolysable tannin that has been approved... (Review)
Review
In recent years, increasing attention has been paid to the pharmacological efficacy of tannins. Tannic acid (TA), the simplest hydrolysable tannin that has been approved by the FDA as a safe food additive, is one of the most important components of these traditional medicines. Studies have shown that TA displays a wide range of pharmacological activities, such as anti-inflammatory, neuroprotective, antitumor, cardioprotective, and anti-pathogenic effects. Here, we summarize the known pharmacological effects and associated mechanisms of TA. We focus on the effect and mechanism of TA in various animal models of inflammatory disease and organ, brain, and cardiovascular injury. Moreover, we discuss the possible molecular targets and signaling pathways of TA, in addition to the pharmacological effects of TA-based nanoparticles and TA in combination with chemotherapeutic drugs.
Topics: Animals; Nanoparticles; Signal Transduction; Tannins
PubMed: 36029537
DOI: 10.1016/j.biopha.2022.113561 -
Journal of Materials Chemistry. B Aug 2022Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic acid with several galloyl groups in its structure. Tannic acid... (Review)
Review
Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic acid with several galloyl groups in its structure. Tannic acid interacts with various organic, inorganic, hydrophilic, and hydrophobic materials such as proteins and polysaccharides hydrogen bonding, electrostatic, coordinative bonding, and hydrophobic interactions. Tannic acid has been studied for various biomedical applications as a natural crosslinker with anti-inflammatory, antibacterial, and anticancer activities. In this review, we focus on TA-based hydrogels for biomaterials engineering to help biomaterials scientists and engineers better realize TA's potential in the design and fabrication of novel hydrogel biomaterials. The interactions of TA with various natural or synthetic compounds are deliberated, discussing parameters that affect TA-material interactions thus providing a fundamental set of criteria for utilizing TA in hydrogels for tissue healing and regeneration. The review also discusses the merits and demerits of using TA in developing hydrogels either through direct incorporation in the hydrogel formulation or indirectly immersing the final product in a TA solution. In general, TA is a natural bioactive molecule with diverse potential for engineering biomedical hydrogels.
Topics: Biocompatible Materials; Hydrogels; Polyphenols; Tannins; Wound Healing
PubMed: 35880440
DOI: 10.1039/d2tb01056a -
Mini Reviews in Medicinal Chemistry 2023Plant-derived tannic acid as a green material can play an important role in improving the mechanical and physical properties of biomaterials. Tannic acid can be used as... (Review)
Review
Plant-derived tannic acid as a green material can play an important role in improving the mechanical and physical properties of biomaterials. Tannic acid can be used as an antioxidant, antimicrobial, and cross-linking agent in biomaterial products due to its unique functional groups. Its active phenolic groups can react with biomaterial functional groups to form bonds that improve performance. In this review, the mechanism of effectiveness of tannic acid as a natural crosslinker in improving the properties of biomaterials for various applications, such as tissue engineering, tissue adhesives, drug delivery, wound healing, and toxicity studies, has been investigated. In general, tannic acid can be a suitable alternative to synthetic crosslinkers in biomaterial applications.
Topics: Biocompatible Materials; Tannins; Wound Healing; Anti-Infective Agents
PubMed: 35733304
DOI: 10.2174/1389557522666220622112959 -
Chemical Communications (Cambridge,... Nov 2022Tannic acid-based functional coatings, as a green, universal and versatile tool to manipulate surface properties, have received extensive attention in the field of... (Review)
Review
Tannic acid-based functional coatings, as a green, universal and versatile tool to manipulate surface properties, have received extensive attention in the field of surface engineering of membranes for oil-in-water emulsion separation. With the rapid development of this field, more flexible and efficient modification strategies for surface engineering of membranes have been developed recently. It is therefore critical to update the broader scientific community on the important advances in this field. Here, we summarize recent progress in surface engineering of membranes with tannic acid-based coatings for oil-in-water emulsion separation. The chemical properties of tannic acid and how to design TA-based functioanl coatings physical/chemical regulation are discussed. The roles of tannic acid in surface engineering of membranes are highlighted and classified into the following five categories: changing surface wettability, adjusting surface charge, constructing catalytic surfaces, forming hydrogel surfaces, and fabricating hybrid separation membranes/layers. Finally, the future outlook and the challenges in this field are discussed.
Topics: Tannins; Emulsions; Wettability; Membranes, Artificial; Water
PubMed: 36305322
DOI: 10.1039/d2cc05102h -
Journal of Materials Chemistry. B Apr 2022Medical devices and surgical implants are necessary for tissue engineering and regenerative medicines. However, the biofouling and microbial colonization on the implant... (Review)
Review
Medical devices and surgical implants are necessary for tissue engineering and regenerative medicines. However, the biofouling and microbial colonization on the implant surface continues to be a major concern, which is difficult to eradicate and typically necessitates either antibiotic therapy or implant removal. As a result, efficient and eco-friendly bioinspired coating strategies for tethering functional materials or molecules on different medical substrates are highly desirable, especially for endowing versatile surface functionalities. Tannic acid (TA), a well-known tea stain polyphenol, has a good affinity for various substrates and actively inhibits the adhesion and colonization of microbes. Thus, functionalization of polymers, nanomaterials, metal-phenolic networks (MPNs), and proteins using TA bestows the end-products with unique binding or anchoring abilities on various implantable surfaces. This review addresses the recent advancements in the essential biomedical perspective of TA-based bioinspired universal surface coating technologies by focusing on their intrinsic features and ability to produce engineered functional composites. Further, the possible contributions of TA-based composites in antifouling and antibacterial applications on various biomedical substrates are outlined.
Topics: Anti-Bacterial Agents; Biofouling; Polymers; Surface Properties; Tannins
PubMed: 35060581
DOI: 10.1039/d1tb02073k -
International Journal of Pharmaceutics Aug 2023In recent years, protein drug development has gained momentum, and simple and facile controlled-release systems without loss of activity are required. Herein, we...
In recent years, protein drug development has gained momentum, and simple and facile controlled-release systems without loss of activity are required. Herein, we developed a sustained-release system for protein drugs by exploiting the "astringency" mechanism, namely insoluble precipitate formation by interacting with tannic acid. Tannic acid formed insoluble precipitates with various protein drugs, such as nisin, insulin, lysozyme, ovalbumin, hyaluronidase, and human immunoglobulin G, through hydrophobic interactions and hydrogen bonds. The lysozyme/tannic acid complex retained in vitro lytic activity. Precipitates of the insulin/tannic acid complex prolonged hypoglycemic effects without loss of activity after subcutaneous administration. The ovalbumin/tannic acid complex enhanced anti-ovalbumin antibody production induced by ovalbumin, which may be attributed to its sustained-release profile. Accordingly, tannic acid is useful as a simple and user-friendly drug delivery system for protein drugs.
Topics: Humans; Muramidase; Delayed-Action Preparations; Tannins; Ovalbumin; Insulins
PubMed: 37454828
DOI: 10.1016/j.ijpharm.2023.123229 -
Food and Cosmetics Toxicology Jul 1969
Review
Topics: Animals; Chemical Phenomena; Chemical and Drug Induced Liver Injury; Chemistry; Coffee; Contrast Media; Drug Contamination; Food Additives; Humans; Intestinal Absorption; Kidney Diseases; Rats; Tannins; Tea
PubMed: 4898705
DOI: No ID Found -
Critical Reviews in Food Science and... Aug 1998Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases... (Review)
Review
Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals. Therefore, foods rich in tannins are considered to be of low nutritional value. However, recent findings indicate that the major effect of tannins was not due to their inhibition on food consumption or digestion but rather the decreased efficiency in converting the absorbed nutrients to new body substances. Incidences of certain cancers, such as esophageal cancer, have been reported to be related to consumption of tannins-rich foods such as betel nuts and herbal teas, suggesting that tannins might be carcinogenic. However, other reports indicated that the carcinogenic activity of tannins might be related to components associated with tannins rather than tannins themselves. Interestingly, many reports indicated negative association between tea consumption and incidences of cancers. Tea polyphenols and many tannin components were suggested to be anticarcinogenic. Many tannin molecules have also been shown to reduce the mutagenic activity of a number of mutagens. Many carcinogens and/or mutagens produce oxygen-free radicals for interaction with cellular macromolecules. The anticarcinogenic and antimutagenic potentials of tannins may be related to their antioxidative property, which is important in protecting cellular oxidative damage, including lipid peroxidation. The generation of superoxide radicals was reported to be inhibited by tannins and related compounds. The antimicrobial activities of tannins are well documented. The growth of many fungi, yeasts, bacteria, and viruses was inhibited by tannins. We have also found that tannic acid and propyl gallate, but not gallic acid, were inhibitory to foodborne bacteria, aquatic bacteria, and off-flavor-producing microorganisms. Their antimicrobial properties seemed to be associated with the hydrolysis of ester linkage between gallic acid and polyols hydrolyzed after ripening of many edible fruits. Tannins in these fruits thus serve as a natural defense mechanism against microbial infections. The antimicrobial property of tannic acid can also be used in food processing to increase the shelf-life of certain foods, such as catfish fillets. Tannins have also been reported to exert other physiological effects, such as to accelerate blood clotting, reduce blood pressure, decrease the serum lipid level, produce liver necrosis, and modulate immunoresponses. The dosage and kind of tannins are critical to these effects. The aim of this review is to summarize and analyze the vast and sometimes conflicting literature on tannins and to provide as accurately as possible the needed information for assessment of the overall effects of tannins on human health.
Topics: Anti-Bacterial Agents; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Food; Health; Humans; Molecular Structure; Tannins
PubMed: 9759559
DOI: 10.1080/10408699891274273 -
Journal of Controlled Release :... Nov 2020Here, we report a tannic acid-Fe coordination complex coating that confers magnetic resonance imaging (MRI) theranostic properties to inert nanomaterials. Boron nitride...
Here, we report a tannic acid-Fe coordination complex coating that confers magnetic resonance imaging (MRI) theranostic properties to inert nanomaterials. Boron nitride nanosheets (BNS), which lack magnetic field and light responsiveness, were used as a model nonfunctional nanomaterial. Among various catechol derivatives tested (i.e., dopamine, 3,4-dihydroxyphenylacetic acid, gallic acid, and tannic acid), a coating of tannic acid-Fe coordination complex provided the highest magnetic field relaxivity and near infrared (NIR) laser light responsiveness. An in vitro study showed that KB tumor cells treated with tannic acid-Fe coordination complex adsorbed on BNS (TA-Fe/BNS) exhibited higher T1-weighted magnetic resonance contrast compared with plain BNS, and BNS coated with tannic acid or Fe alone. NIR irradiation at 808 nm caused a significant increase in KB tumor cell death after treatment with TA-Fe/BNS compared with other treatments. In vivo MRI imaging revealed tumor accumulation of intravenously administered TA-Fe/BNS. Guided by MRI information, application of focused laser irradiation onto tumor tissues resulted in complete tumor ablation. These results support the potential of TA-Fe/BNS for MRI theranostics. Moreover, this study suggests the wide applicability of TA-Fe noncovalent coating as biocompatible and facile tool for converting nonfunctional early-generation nanomaterials into functional new nanomaterials, opening new opportunities for their use in translational biomedical applications such as MRI theranostics.
Topics: Boron Compounds; Nanostructures; Precision Medicine; Tannins
PubMed: 32916228
DOI: 10.1016/j.jconrel.2020.09.009 -
Molecules (Basel, Switzerland) Mar 2021Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall nuts and other plant sources. A myriad of pharmaceutical and biological... (Review)
Review
Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall nuts and other plant sources. A myriad of pharmaceutical and biological applications in the medical field has been well recognized to tannic acid. Among these effects, potential anticancer activities against several solid malignancies such as liver, breast, lung, pancreatic, colorectal and ovarian cancers have been reported. Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes. The combinational beneficial effects of tannic acid with other conventional chemotherapeutic drugs have been clearly demonstrated in literature such as a synergistic anticancer effect and enhancement of the chemo-sensitivity in several resistant cases. Yet, clinical applications of tannic acid have been limited owing to its poor lipid solubility, low bioavailability, off-taste, and short half-life. To overcome such obstacles, novel drug delivery systems have been employed to deliver tannic acid with the aim of improving its applications and/or efficacy against cancer cells. Among these drug delivery systems are several types of organic and metallic nanoparticles. In this review, the authors focus on the molecular mechanisms of tannic acid in tuning several neoplastic diseases as well as novel drug delivery systems that can be used for its clinical applications with an attempt to provide a systemic reference to promote the development of tannic acid as a cheap drug and/or drug delivery system in cancer management.
Topics: Antineoplastic Agents; Drug Delivery Systems; Humans; Hydrolyzable Tannins; Nanoparticles; Neoplasms; Tannins
PubMed: 33803294
DOI: 10.3390/molecules26051486