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Revista Clinica Espanola Dec 1969
Review
Topics: Blood Platelet Disorders; Blood Protein Disorders; Hepatitis; Humans; Leukemia; Liver Cirrhosis; Liver Diseases; Thrombocytosis; Uremia
PubMed: 4932158
DOI: No ID Found -
Haemophilia : the Official Journal of... May 2014The diagnosis and management of bleeding disorders is made difficult by the complexity and variety of disorders, clinical symptoms and bleeding type and severity. von... (Review)
Review
The diagnosis and management of bleeding disorders is made difficult by the complexity and variety of disorders, clinical symptoms and bleeding type and severity. von Willebrand disease (VWD) and platelet disorders are disorders of primary haemostasis and together represent the most common inherited bleeding disorders. In this article, we describe the diagnosis of VWD and platelet disorders and the treatment options for VWD.
Topics: Blood Coagulation Tests; Blood Platelet Disorders; Hemostasis; Hemostatics; Humans; Premedication; von Willebrand Diseases
PubMed: 24762277
DOI: 10.1111/hae.12414 -
Haemophilia : the Official Journal of... Jul 2000Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic;... (Review)
Review
Platelet function defects comprise a large and heterogeneous group of bleeding disorders that range in severity from mild to severe. Patients may be asymptomatic; however, the majority who are diagnosed present with easy bruising and mucocutaneous bleeding, or with excessive haemorrhage following injury or surgery. As the complex internal biochemical and signal transduction pathways are further understood, and as structural analysis of platelets advances, more of the mechanisms leading to platelet function defects will be uncovered. Despite advances in the understanding of the etiology of these defects in function, treatment remains fairly rudimentary. For platelet function disorders associated with a defect in a plasma coagulation factor, such as vWD and afibrinogenemia, treatment consists of replacement of the deficient coagulation factor. Adjunctive therapies (such as antifibrinolytics, microfibular collagen, fibrin glue, etc.), DDAVP/Stimate, and platelet transfusions remain the mainstay of therapy available at this time. Corticosteroids may play a role in the management of some of these disorders and may lead to a shortening of bleeding time, especially in storage pool defects or release defects failing to respond to DDAVP/Stimate.
Topics: Animals; Blood Platelet Disorders; Blood Platelets; Hemostasis; Humans; Platelet Function Tests
PubMed: 10982278
DOI: 10.1046/j.1365-2516.2000.00056.x -
Hamostaseologie 2015Although platelets act as central players of haemostasis only their cross-talk with other blood cells, plasma factors and the vascular compartment enables the formation... (Review)
Review
Although platelets act as central players of haemostasis only their cross-talk with other blood cells, plasma factors and the vascular compartment enables the formation of a stable thrombus. Multiple activation processes and complex signalling networks are responsible for appropriate platelet function. Thus, a variety of platelet function tests are available for platelet research and diagnosis of platelet dysfunction. However, universal platelet function tests that are sensitive to all platelet function defects do not exist and therefore diagnostic algorithms for suspected platelet function disorders are still recommended in clinical practice. Based on the current knowledge of human platelet activation this review evaluates point-of-care related screening tests in comparison with specific platelet function assays and focuses on their diagnostic utility in relation to severity of platelet dysfunction. Further, systems biology-based platelet function methods that integrate global and specific analysis of platelet vessel wall interaction (advanced flow chamber devices) and post-translational modifications (platelet proteomics) are presented and their diagnostic potential is addressed.
Topics: Blood Platelet Disorders; Blood Platelets; Humans; Platelet Function Tests; Point-of-Care Systems; Reproducibility of Results; Sensitivity and Specificity
PubMed: 25482925
DOI: 10.5482/HAMO-14-09-0047 -
Blood Reviews Nov 2022The last decade has seen large increases in the number of patients registered with heritable platelet disorders in national databases of bleeding disorders. Although... (Review)
Review
The last decade has seen large increases in the number of patients registered with heritable platelet disorders in national databases of bleeding disorders. Although individually rare, collectively they are a relatively common cause of heritable bleeding. This revolution has come about through the application of high-throughput sequencing strategies and efforts to standardize diagnostic testing. There is renewed interest in established parameters such as platelet volume and utilising simple tools such as blood smears. The diagnostic yield from peripheral blood smears can be improved with new microscopy techniques that could potentially assist in determining which patients need to be referred to tertiary centres for specialist testing. A better understanding of the other clinical features that can accompany abnormalities of platelet number or function, can lead to better clinical management and prevention of serious complications. There are challenges for clinicians who need to be aware of these developments, understand the limitations of new diagnostic techniques and keep abreast of strategies for incorporation into clinical practice. This review discusses some of these approaches, the limitations that clinicians need to be aware of and techniques that may enter clinical use in the future.
Topics: Humans; Blood Platelet Disorders; Blood Platelets; Hemorrhage; Blood Coagulation Disorders; High-Throughput Nucleotide Sequencing
PubMed: 35595614
DOI: 10.1016/j.blre.2022.100972 -
Turk Tip Cemiyeti Mecmuasi Sep 1960
Topics: Blood Platelet Disorders; Hematologic Diseases; Hemorrhagic Disorders; Humans; Uremia
PubMed: 13717649
DOI: No ID Found -
La Pediatria Mar 1978
Topics: Adult; Antigen-Antibody Complex; Blood Coagulation Tests; Blood Platelet Disorders; Female; Humans; Immunoglobulins; Immunosuppressive Agents; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Factor 3; Vasculitis; Vasculitis, Leukocytoclastic, Cutaneous
PubMed: 567317
DOI: No ID Found -
Acta Haematologica 1990A new type of primary thrombocytopathy is described. Three main alterations were found: (1) a defect of the aggregation reaction with ADP, epinephrine and collagen and a...
A new type of primary thrombocytopathy is described. Three main alterations were found: (1) a defect of the aggregation reaction with ADP, epinephrine and collagen and a normal response to ristocetin and arachidonic acid; (2) a moderate deficiency of platelet procoagulant activity, and (3) a combined hypertrophy of the two membrane systems of the platelet--the open canalicular and the dense tubular. The latter defect is shown as an abnormal membrane complex situated on one of the platelet poles. This thrombocytopathy is discussed as a new variety of primary platelet disorder.
Topics: Adult; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Diagnosis, Differential; Female; Humans; Microscopy, Electron; Platelet Adhesiveness; Platelet Aggregation; Platelet Count; Surface Properties
PubMed: 2106203
DOI: 10.1159/000205178 -
Hamostaseologie Feb 2023Platelets play an important role regarding coagulation by contributing to thrombus formation by platelet adhesion, aggregation, and α-/δ-granule secretion. Inherited...
Platelets play an important role regarding coagulation by contributing to thrombus formation by platelet adhesion, aggregation, and α-/δ-granule secretion. Inherited platelet disorders (IPDs) are a very heterogeneous group of disorders that are phenotypically and biochemically diverse. Platelet dysfunction (thrombocytopathy) can be accompanied by a reduction in the number of thrombocytes (thrombocytopenia). The extent of the bleeding tendency can vary greatly. Symptoms comprise mucocutaneous bleeding (petechiae, gastrointestinal bleeding and/or menorrhagia, epistaxis) and increased hematoma tendency. Life-threatening bleeding can occur after trauma or surgery. In the last years, next-generation sequencing had a great impact on unrevealing the underlying genetic cause of individual IPDs. Because IPDs are so diverse, a comprehensive analysis of platelet function and genetic testing is indispensable.
Topics: Female; Humans; Blood Platelet Disorders; Blood Coagulation Disorders; Blood Platelets; Hemorrhagic Disorders; Thrombocytopenia
PubMed: 36807820
DOI: 10.1055/a-1987-3310 -
Pediatric Clinics of North America Dec 2013Inherited platelet function disorders are of variable severity and unknown frequency and may be difficult to diagnose. Nevertheless, they are increasingly recognized as... (Review)
Review
Inherited platelet function disorders are of variable severity and unknown frequency and may be difficult to diagnose. Nevertheless, they are increasingly recognized as an important cause of bleeding in pediatrics, particularly in adolescent girls with menorrhagia, where they may be more common than von Willebrand disease. This article reviews the presentation of these disorders, summarizes the most common types of platelet function disorders, discusses the challenges in diagnostic testing, and details treatment and supportive care options.
Topics: Adolescent; Blood Platelet Disorders; Blood Platelets; Child; Child, Preschool; Diagnosis, Differential; Female; Hemorrhage; Hemostasis; Humans; Platelet Function Tests
PubMed: 24237983
DOI: 10.1016/j.pcl.2013.08.004