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Bailliere's Clinical Haematology Jul 1989
Review
Topics: Blood Platelet Disorders; Blood Platelets; Genetic Carrier Screening; Humans; Platelet Membrane Glycoproteins; Thrombasthenia
PubMed: 2673430
DOI: 10.1016/s0950-3536(89)80036-8 -
The New England Journal of Medicine Feb 1970
Review
Topics: Blood Cell Count; Blood Platelet Disorders; Blood Platelets; Hematopoiesis; Humans; Megakaryocytes; Thrombocytopenia; Thrombocytosis
PubMed: 4905441
DOI: 10.1056/NEJM197002262820906 -
Journal of Veterinary Emergency and... Feb 2012To review the current in vivo and in vitro tests of platelet function (PF) currently available and applicable to companion animals. (Review)
Review
OBJECTIVE
To review the current in vivo and in vitro tests of platelet function (PF) currently available and applicable to companion animals.
DATA SOURCES
Scientific reviews, case reports, original clinical and laboratory research publications, and recent veterinary research conference proceedings.
HUMAN DATA SYNTHESIS
Disorders of primary hemostasis are very common in human medicine. These include inborn errors of PF and granule storage contents, primary disease mechanisms that alter PF, disorders secondary to surgical interventions, and the effects of anticoagulant medications. Knowledge of PF disorders and the optimal method for assessment must be known to understand the mechanism and to monitor the process or drug therapy.
VETERINARY DATA SYNTHESIS
Interest in the study and treatment of primary coagulopathies in clinical veterinary patients has resulted in a surge of recent publications and scientific research presentations. A translational approach that uses laboratory and point-of-care tools to uncover the pathophysiologic mechanisms in the patient with defects in primary hemostasis allows the clinician to plan the diagnosis and treatment more effectively.
SUMMARY
Primary hemostatic disorders are being more commonly recognized in clinical veterinary practice. The diagnosis of platelet dysfunction may be obtained via point-of-care analyzers that use relatively small blood samples and have a quick turnaround time. Recent investigations may lead to a better understanding of the pathophysiology of PF disorders and potentially the optimization, or discovery, of novel treatments.
CONCLUSIONS
The assessment of PF can be completed through in vivo and in vitro point-of-care techniques as well as by submission of blood samples to more specialized platelet biology laboratories. The information obtained including the physical examination and clinical manifestations of a hemostatic disorder, as well as the benefits of each testing modality, must be known prior to the diagnostic investigation of a patient with a coagulopathy.
Topics: Animals; Blood Platelet Disorders; Blood Platelets; Platelet Function Tests
PubMed: 23016745
DOI: 10.1111/j.1476-4431.2011.00707.x -
Clinics in Perinatology Sep 1980
Review
Topics: Blood Platelet Disorders; Blood Platelets; Disseminated Intravascular Coagulation; Female; Humans; Platelet Count; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Hematologic; Purpura, Thrombocytopenic; Purpura, Thrombotic Thrombocytopenic; Thrombocytosis
PubMed: 7002423
DOI: No ID Found -
Journal of Thrombosis and Haemostasis :... Jul 2003Inherited platelet-based bleeding disorders include abnormalities of platelet number and function, and are generally classified based on the abnormal functions or... (Review)
Review
Inherited platelet-based bleeding disorders include abnormalities of platelet number and function, and are generally classified based on the abnormal functions or responses. However, a clear distinction is problematic, and in this review, the classification has been based on abnormalities of platelet components that share common characteristics. Inherited thrombocytopenias are rare, but probably underdiagnosed. They are usually classified according to both platelet size and the presence or absence of clinical features other than those deriving from the platelet defect. Hereditary disorders of platelet function can be classified as resulting from: (i) abnormalities of the platelet receptors for adhesive proteins; (ii) abnormalities of the platelet receptors for soluble agonists; (iii) abnormalities of the platelet granules; (iv) abnormalities of the signal-transduction pathways; (v) abnormalities of the membrane phospholipids; and (vi) miscellaneous abnormalities of platelet function. The literature on these disorders is reviewed, and the underlying defects discussed.
Topics: Blood Platelet Disorders; Hemorrhage; Humans; Thrombocytopenia
PubMed: 12871299
DOI: 10.1046/j.1538-7836.2003.00266.x -
Seminars in Thrombosis and Hemostasis Oct 2019Recent advances in genetic analysis are bringing huge benefits to patients with rare genetic disorders, including those with inherited disorders of platelet number and... (Review)
Review
Recent advances in genetic analysis are bringing huge benefits to patients with rare genetic disorders, including those with inherited disorders of platelet number and function. Modern clinical hematological practice now has a range of genetic techniques available to enable the precision diagnosis of inherited platelet disorders (IPDs). There are some features of this disparate group of inherited disorders that present specific challenges to establishing an accurate genetic diagnosis. This review aims to introduce the techniques that are relevant for the genetic diagnosis of IPDs and will discuss the key considerations necessary for their application to the clinic.
Topics: Blood Platelet Disorders; Genetic Testing; High-Throughput Nucleotide Sequencing; Humans
PubMed: 31041802
DOI: 10.1055/s-0039-1687888 -
Thrombosis Et Diathesis Haemorrhagica.... 1967
Topics: Animals; Blood Coagulation Tests; Blood Platelet Disorders; Chromosome Aberrations; Chromosome Disorders; Clot Retraction; Dog Diseases; Dogs; Female; Male; Microscopy, Electron
PubMed: 6064862
DOI: No ID Found -
The American Journal of Medicine Feb 1963
Topics: Blood Platelet Disorders; Hematologic Diseases; Humans; von Willebrand Diseases
PubMed: 13971750
DOI: 10.1016/0002-9343(63)90057-3 -
Der Internist Sep 2010Inherited thrombocytopathies are much less frequent in comparison to acquired platelet function disorders. However, congenital disorders can lead to severe bleeding... (Review)
Review
Inherited thrombocytopathies are much less frequent in comparison to acquired platelet function disorders. However, congenital disorders can lead to severe bleeding tendency and are often not diagnosed. They are induced by different platelet defects based on disorders of platelet adhesion, receptors, secretion and signal transduction. In some cases they are associated with thrombocytopenia, giant platelets and various comorbidities. This article gives an overview regarding diverse defects, their diagnosis and treatment options.
Topics: Bernard-Soulier Syndrome; Blood Platelet Disorders; Blood Platelets; Diagnosis, Differential; Genotype; Hemorrhagic Disorders; Humans; Mass Screening; Platelet Aggregation; Platelet Function Tests; Platelet Storage Pool Deficiency; Prostaglandin-Endoperoxide Synthases; Receptors, Collagen; Thrombasthenia; Thromboxane-A Synthase
PubMed: 20725709
DOI: 10.1007/s00108-010-2596-3 -
Hematology. American Society of... 2011Platelet dysfunction is commonly acquired due to medications, procedures, medical conditions, and underlying hematologic disease. These issues are presented, the data... (Review)
Review
Platelet dysfunction is commonly acquired due to medications, procedures, medical conditions, and underlying hematologic disease. These issues are presented, the data reviewed, and recommendations given herein. Many medications and dietary supplements have platelet-inhibitory effects in vitro, although the clinical effects on bleeding risks are unclear for many. Platelet-inhibitory drugs are key in the treatment of vascular disease. Data are available to aid in the management of these medications to prevent hemorrhagic complications. Bleeding in patients with renal failure has decreased with improved dialysis and the use of erythropoietin, but remains a challenge. Platelet dysfunction accompanies cardiac valvular disease and use of cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation. Hematologic disorders including myeloproliferative disorders (MPDs), myelodysplasia, paraproteinemias, and immune thrombocytopenia (ITP) can also be associated with hemorrhagic complications due to platelet dysfunction. Knowledge of which factors affect bleeding risk and how to treat individuals with acquired platelet dysfunction are important in optimizing patient care.
Topics: Blood Platelet Disorders; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Humans
PubMed: 22160063
DOI: 10.1182/asheducation-2011.1.391