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Wiener Klinische Wochenschrift Oct 2004
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Follow-Up Studies; Glossectomy; Humans; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Radiography; Tongue; Tongue Neoplasms
PubMed: 15941070
DOI: 10.1007/s00508-004-0244-4 -
Journal of Cancer Research and... Jan 2018Tongue cancer is one of the most common and deadly types of head and neck cancer. The incidence of tongue cancer has been particularly high and remained been increasing... (Review)
Review
Tongue cancer is one of the most common and deadly types of head and neck cancer. The incidence of tongue cancer has been particularly high and remained been increasing in some countries. A main reason for poor prognosis and clinical outcome for tongue cancer was its resistance to chemotherapies, behind which the mechanisms have been not clear. In this review, we summarized literatures published in recent years and listed the proteins, biomacromolecules, and signaling pathways related to this drug resistance. We hoped that this summary could provide reference for researchers to develop new treatment strategies for tongue cancer.
Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Tongue Neoplasms
PubMed: 29516950
DOI: 10.4103/jcrt.JCRT_763_17 -
Cancer Imaging : the Official... Dec 2006The tongue enables taste and plays a critical role in formation of food bolus and deglutition. The tongue is also crucial for speech and the earliest sign of tongue... (Review)
Review
The tongue enables taste and plays a critical role in formation of food bolus and deglutition. The tongue is also crucial for speech and the earliest sign of tongue paresis is a change in the quality of speech. Given the importance of the tongue, tongue carcinoma should be accurately staged in order to optimise treatment options and preserve organ function. The intent of this review is to familiarize radiologists with the pertinent anatomy of the tongue and the behaviour of tongue carcinoma so as to map malignant infiltration accurately.
Topics: Humans; Magnetic Resonance Imaging; Neoplasm Staging; Tomography, X-Ray Computed; Tongue; Tongue Neoplasms
PubMed: 17208674
DOI: 10.1102/1470-7330.2006.0029 -
Odontology Jan 2017Adenosquamous carcinoma (ASC) of the tongue is an uncommon malignant oral neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive... (Review)
Review
Adenosquamous carcinoma (ASC) of the tongue is an uncommon malignant oral neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior. Here, we report a rare case of ASC of the lateral border of the tongue in a 65-year-old Japanese man. The patient was treated by radical operation and remained well for 6 months before developing metastasis of the hilar and pretracheal lymph nodes. Subsequently, the patient was treated with combined chemotherapy (nedaplatin plus docetaxel and S-1 for two cycles, intravenously) and radiotherapy. Radiation therapy of metastatic lymph nodes was performed at a total dose of 60 Gy and was delivered in 2 Gy fractions 5 days/week. The patient is currently tumor free and is being followed up carefully. This article describes a rare case of ASC of the tongue and its conventional histologic, immunohistochemical, and electron microscopic findings, together with a review of the literature. The findings provide important information to better understand the possible clinical and therapeutic approaches for this uncommon tumor of the tongue.
Topics: Aged; Carcinoma, Adenosquamous; Diagnostic Imaging; Humans; Immunohistochemistry; Male; Microscopy, Electron; Tongue Neoplasms
PubMed: 27456683
DOI: 10.1007/s10266-016-0261-6 -
The Laryngoscope Feb 2013Chondrosarcoma of the head and neck is uncommon and reported to constitute between 1% to 12% of all chondrosarcoma cases.1, 2, 3 Extraskeletal chondrosarcoma of the... (Review)
Review
Chondrosarcoma of the head and neck is uncommon and reported to constitute between 1% to 12% of all chondrosarcoma cases.1, 2, 3 Extraskeletal chondrosarcoma of the tongue is an extremely rare type of neoplasm with only three previously reported cases. The underlying origin of chondrosarcoma arising in the tongue is controversial. We describe a case of a low-grade chondrosarcoma arising in the base of the tongue of a 54-year-old woman with a central area of dedifferentiation. The patient was treated with complete surgical resection with no evidence of recurrence at 1 year follow-up.
Topics: Biopsy; Chondrosarcoma; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Tomography, X-Ray Computed; Tongue Neoplasms
PubMed: 22951904
DOI: 10.1002/lary.23658 -
BMJ Case Reports Jul 2018The glomus tumour is a rare neoplasm derived from the glomus apparatus. Subungual sites are most common with only three published cases involving the dorsal tongue. To...
The glomus tumour is a rare neoplasm derived from the glomus apparatus. Subungual sites are most common with only three published cases involving the dorsal tongue. To our knowledge, this is the first case of an intraoral malignant glomus tumour (glomangiosarcoma) to be published in English literature. We report a case of a single glomus tumour located on the posterior dorsal tongue of a middle-aged man, which was surgically excised. Immunohistological features were indicative of a glomus tumour; however, in this case, malignant features were also discovered, warranting re-excision.
Topics: Biopsy, Fine-Needle; Glomus Tumor; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Reoperation; Tongue Neoplasms
PubMed: 29973409
DOI: 10.1136/bcr-2017-223268 -
Oral Diseases Jul 2023To obtain the relative volume by measuring the tongue volume and the lesion volume, and further explore its relationship with the prognosis of patients, hoping to...
PURPOSE
To obtain the relative volume by measuring the tongue volume and the lesion volume, and further explore its relationship with the prognosis of patients, hoping to supplement the TNM staging with a new index.
METHODS
ITK-SANP software was used to outline the patients' MRI. After MRI reconstruction and measurement, slicer software was used to estimate tumor volume.
RESULTS
A total of 64 patients with tongue cancer who met the inclusion criteria were included in the study. The estimated tumor volume after MRI reconstruction revealed a significant and robust correlation with tumor stage (p < 0.05, Rs = 0.6207) and a substantial and medium correlation with early lymph node metastasis (p < 0.05, Rs = 0.4873).
CONCLUSIONS
We classified tongue cancer into three grades based on tumor volume (Stage I, tumors smaller than 1500 mm³; Stage II, tumors 1500-9000 mm³; and Stage III, tumors larger than 9000 mm³), and such grading could be used as a reference for tumor staging, lymph node metastasis, and patient prognosis to a certain extent.
Topics: Humans; Tongue Neoplasms; Lymphatic Metastasis; Retrospective Studies; Prognosis; Neoplasm Staging; Magnetic Resonance Imaging; Tongue; Lymph Nodes
PubMed: 35426211
DOI: 10.1111/odi.14212 -
Otolaryngologic Clinics of North America Feb 2005The management of base of tongue cancer has evolved steadily over time. Organ preservation with primary radiation therapy has produced excellent oncologic and functional... (Review)
Review
The management of base of tongue cancer has evolved steadily over time. Organ preservation with primary radiation therapy has produced excellent oncologic and functional outcomes. Concomitant chemotherapy has become important in patients with locoregionally advanced disease. Planned neck dissection after organ preservation therapy continues to be an integral step for regional control. This article reports the results of a literature review of base of tongue cancer emphasizing a multidisciplinary approach to obtain optimal results in terms of cure and quality of life.
Topics: Antineoplastic Agents; Chemotherapy, Adjuvant; Glossectomy; Humans; Neoplasm Staging; Quality of Life; Radiotherapy, Adjuvant; Tongue Neoplasms; Treatment Outcome
PubMed: 15649500
DOI: 10.1016/j.otc.2004.10.016 -
The Surgical Clinics of North America Feb 1973
Topics: Bleomycin; Carcinoma, Squamous Cell; Dental Caries; Electrocoagulation; Fluorides, Topical; Fluorouracil; Glossectomy; Humans; Lymphatic Metastasis; Methotrexate; Neck Dissection; Neoplasm Metastasis; Neoplasm Recurrence, Local; Preoperative Care; Radiotherapy Dosage; Tongue Neoplasms
PubMed: 4122157
DOI: 10.1016/s0039-6109(16)39940-6 -
The British Journal of Oral &... Jan 2021Complete tumour resection (R0 margin) is an axiom of surgical oncology. Oral cancer ablation is challenging, due to anatomical, functional, and aesthetic considerations....
Complete tumour resection (R0 margin) is an axiom of surgical oncology. Oral cancer ablation is challenging, due to anatomical, functional, and aesthetic considerations. R0 margin is strongly linked to better survival outcomes with great variation in the R0 % across units. This is commonly attributed to disease biology. Without disputing the importance of biological characteristics, we contend that image-based anatomical surgical planning has an important role to play in achieving complete resection. Here, we present our approach utilising cross-sectional imaging, anatomical characteristics and spatial awareness in planning resections for floor of mouth (FOM) and oral tongue cancers. We highlight the challenge of controlling the deep tumour margin lingual to mandible due to anterior vector constraints and emphasise the importance of resecting the genial muscles in a planned fashion and that any rim resection should be obliquely sagittal. In resecting lateral FOM tumours, assessing extension to the parapharyngeal fat is crucial; and mandibular rim resection at a sagittal plane below the mylohyoid line is often required. Assessing the proximity of the contralateral neurovascular pedicle, pre-epiglottic space and hyoid bone are crucial parameters to determine the extent of tongue tumour resection. Our cohort included 173 patients with FOM SCC and 299 patients with tongue SCC. Six patients (3.5%) from the FOM group and eight patients (3%) from the tongue group had involved (R1) margins following surgery. This was associated with local relapse (p<0.05). In conclusion, we demonstrate that image-based planning can aid achieving R0 resections and reduce disease relapse.
Topics: Esthetics, Dental; Head and Neck Neoplasms; Humans; Mouth Floor; Neoplasm Recurrence, Local; Neoplasm Staging; Tongue; Tongue Neoplasms
PubMed: 33143945
DOI: 10.1016/j.bjoms.2020.08.118