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Revista Do Instituto de Medicina... 2021The aim of this study was to establish an evidence-based guideline for the antibiotic treatment of Corynebacterium striatum infections. Several electronic databases were...
The aim of this study was to establish an evidence-based guideline for the antibiotic treatment of Corynebacterium striatum infections. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with systemic inflammatory response syndrome, harboring C. striatum isolated from body fluids or tissues in which it is not normally present. C. striatum had to be identified as the only causative agent of the invasive infection, and its isolation from blood, body fluids or tissues had to be confirmed by one of the more advanced diagnostic methods (biochemical methods, mass spectrometry and/or gene sequencing). This systematic review included 42 studies that analyzed 85 individual cases with various invasive infections caused by C. striatum. More than one isolate of C. striatum exhibited 100% susceptibility to vancomycin, linezolid, teicoplanin, piperacillin-tazobactam, amoxicillin-clavulanate and cefuroxime. On the other hand, some strains of this bacterium showed a high degree of resistance to fluoroquinolones, to the majority majority of β-lactams, aminoglycosides, macrolides, lincosamides and cotrimoxazole. Despite the antibiotic treatment, fatal outcomes were reported in almost 20% of the patients included in this study. Gene sequencing methods should be the gold standard for the identification of C. striatum, while MALDI-TOF and the Vitek system can be used as alternative methods. Vancomycin should be used as the antibiotic of choice for the treatment of C. striatum infections, in monotherapy or in combination with piperacillin-tazobactam. Alternatively, linezolid, teicoplanin or daptomycin may be used in severe infections, while amoxicillin-clavulanate may be used to treat mild infections caused by C. striatum.
Topics: Aminoglycosides; Anti-Bacterial Agents; Corynebacterium; Corynebacterium Infections; Humans; Microbial Sensitivity Tests
PubMed: 34161555
DOI: 10.1590/S1678-9946202163049 -
Archivos Espanoles de Urologia Jul 2021Encrusted pyelitis in an infection caused by Corynebacterium Urealyticum. The incidence has increased, specially in immunosuppressed patients and patients with...
OBJECTIVE
Encrusted pyelitis in an infection caused by Corynebacterium Urealyticum. The incidence has increased, specially in immunosuppressed patients and patients with indwelling urinary catheters.
METHODS
We are presenting a case of a 72 years old male with Bricker urinary derivation with an ureteral catheter. During the follow up, catheteral calcification and encrusted pyelitis were found in TC images and cultures were positive for Corynebacteirum Urealitycum. This condition was managed with endoscopic and medical treatment; that consisted in antibiotics and acidification of urine through nephrostomy tube using an acidifying irrigation solution and Lit-Control pH Down orally, in order to avoid new infections.
RESULTS
Treatment was effective, no new reinfections were shown with the use of Lit-Control pH Down for the maintenance.
CONCLUSIONS
The suspected diagnosis and the early treatment of encrusted pyelitis avoid complications. Antibiotics and urine acidification are key in the treatment of this disease.
Topics: Aged; Corynebacterium; Corynebacterium Infections; Humans; Male; Pyelitis; Urinary Catheters
PubMed: 34219065
DOI: No ID Found -
Revista Chilena de Infectologia :... Oct 2021
Topics: Corynebacterium; Corynebacterium Infections; Humans
PubMed: 35506835
DOI: 10.4067/s0716-10182021000500689 -
Revista Chilena de Infectologia :... Dec 2019
Topics: Corynebacterium; Corynebacterium Infections; Humans
PubMed: 33660756
DOI: 10.4067/S0716-10182019000600763 -
Revista Chilena de Infectologia :... Apr 2018
Topics: Animals; Bacterial Typing Techniques; Chile; Corynebacterium diphtheriae; Diphtheria; Erythromycin; Penicillin G
PubMed: 29912257
DOI: 10.4067/s0716-10182018000200189 -
Frontiers in Cellular and Infection... 2020and are common bacteria of the human ear. They have frequently been isolated from the middle ear of children with otitis media (OM), though their potential role in... (Review)
Review
and are common bacteria of the human ear. They have frequently been isolated from the middle ear of children with otitis media (OM), though their potential role in this disease remains unclear and confounded due to their presence as commensal inhabitants of the external auditory canal. In this review, we summarize the current literature on these organisms with an emphasis on their role in OM. Much of the literature focuses on the presence and abundance of these organisms, and little work has been done to explore their activity in the middle ear. We find there is currently insufficient evidence available to determine whether these organisms are pathogens, commensals or contribute indirectly to the pathogenesis of OM. However, building on the knowledge currently available, we suggest future approaches aimed at providing stronger evidence to determine whether and are involved in the pathogenesis of OM. Such evidence will increase our understanding of the microbial risk factors contributing to OM and may lead to novel treatment approaches for severe and recurrent disease.
Topics: Bacteria; Carnobacteriaceae; Child; Corynebacterium; Humans; Otitis Media
PubMed: 32117817
DOI: 10.3389/fcimb.2020.00051 -
Periodontology 2000 Jun 2021Ecologists have long recognized the importance of spatial scale in understanding structure-function relationships among communities of organisms within their... (Review)
Review
Ecologists have long recognized the importance of spatial scale in understanding structure-function relationships among communities of organisms within their environment. Here, we review historical and contemporary studies of dental plaque community structure in the context of three distinct scales: the micro (1-10 µm), meso (10-100 µm) and macroscale (100 µm to ≥1 cm). Within this framework, we analyze the compositional nature of dental plaque at the macroscale, the molecular interactions of microbes at the microscale, and the emergent properties of dental plaque biofilms at the mesoscale. Throughout our analysis of dental plaque across spatial scales, we draw attention to disease and health-associated structure-function relationships and include a discussion of host immune involvement in the mesoscale structure of periodontal disease-associated biofilms. We end with a discussion of two filamentous organisms, Fusobacterium nucleatum and Corynebacterium matruchotii, and their relevant contributions in structuring dental plaque biofilms.
Topics: Biofilms; Corynebacterium; Dental Plaque; Fusobacterium nucleatum; Humans; Microbiota
PubMed: 33690940
DOI: 10.1111/prd.12364 -
Microbiological Research Sep 2022L-lysine is one of the amino acids necessary for humans and animals and widely used in food processing, pharmaceutical preparations and feed additives. In recent years,... (Review)
Review
L-lysine is one of the amino acids necessary for humans and animals and widely used in food processing, pharmaceutical preparations and feed additives. In recent years, rational design based on systems metabolic engineering and conventional optimization of fermentation parameters have contributed to the high production of L-lysine. As the demand for L-lysine in the world market is increasing year by year, intensive research has been devoted to efficient productivity and economic production costs. This review briefly explains the biosynthesis and regulation mechanism of L-lysine in Corynebacterium glutamicum, and then outlines the construction, scale-up culture, and product separation and purification strategies of L-lysine high-producing strains. In addition, emerging strategies for the breeding and fermentation of C. glutamicum for the production of L-lysine have been emphatically elucidated. In short, the commercialization of L-lysine production requires chassis strains with excellent production performance, efficient fermentation process, and the development of sustainable purification technologies.
Topics: Amino Acids; Corynebacterium glutamicum; Fermentation; Humans; Lysine; Metabolic Engineering
PubMed: 35803058
DOI: 10.1016/j.micres.2022.127101 -
Molecular Microbiology Dec 2018The WhiB-like (Wbl) family of proteins are exclusively found in Actinobacteria. Wbls have been shown to play key roles in virulence and antibiotic resistance in... (Review)
Review
The WhiB-like (Wbl) family of proteins are exclusively found in Actinobacteria. Wbls have been shown to play key roles in virulence and antibiotic resistance in Mycobacteria and Corynebacteria, reflecting their importance during infection by the human pathogens Mycobacterium tuberculosis, Mycobacterium leprae and Corynebacterium diphtheriae. In the antibiotic-producing Streptomyces, several Wbls have important roles in the regulation of morphological differentiation, including WhiB, a protein that controls the initiation of sporulation septation and the founding member of the Wbl family. In recent years, genome sequencing has revealed the prevalence of Wbl paralogues in species throughout the Actinobacteria. Wbl proteins are small (generally ~80-140 residues) and each contains four invariant cysteine residues that bind an O - and NO-sensitive [4Fe-4S] cluster, raising the question as to how they can maintain distinct cellular functions within a given species. Despite their discovery over 25 years ago, the Wbl protein family has largely remained enigmatic. Here I summarise recent research in Mycobacteria, Corynebacteria and Streptomyces that sheds light on the biochemical function of Wbls as transcription factors and as potential sensors of O and NO. I suggest that Wbl evolution has created diversity in protein-protein interactions, [4Fe-4S] cluster-sensitivity and the ability to bind DNA.
Topics: Bacterial Proteins; Corynebacterium; Gene Expression Regulation, Bacterial; Mycobacterium; Streptomyces; Transcription Factors
PubMed: 30179278
DOI: 10.1111/mmi.14117 -
Emerging Infectious Diseases Aug 2023Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to... (Review)
Review
Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C. ulcerans is widely distributed in the environment and is considered one of the most harmful pathogens to livestock and wildlife. Infection with C. ulcerans can cause respiratory or nonrespiratory symptoms in patients. Recently, the microorganism has been increasingly recognized as an emerging zoonotic agent of diphtheria-like illness in Japan. To clarify the overall clinical characteristics, treatment-related factors, and outcomes of C. ulcerans infection, we analyzed 34 cases of C. ulcerans that occurred in Japan during 2001-2020. During 2010-2020, the incidence rate of C. ulcerans infection increased markedly, and the overall mortality rate was 5.9%. It is recommended that adults be vaccinated with diphtheria toxoid vaccine to prevent the spread of this infection.
Topics: Adult; Humans; Diphtheria; Japan; Corynebacterium; Corynebacterium Infections; Corynebacterium diphtheriae; Diphtheria Toxin; Diphtheria Toxoid
PubMed: 37486266
DOI: 10.3201/eid2908.220058