Immunologic Factor
adalimumab
Brand Names:
Humira
Effect:
Immunologic Activity Alteration
May Treat:
Arthritis, Juvenile;
Arthritis, Psoriatic;
Arthritis, Rheumatoid;
Colitis, Ulcerative;
Crohn Disease;
Hidradenitis Suppurativa;
Spondylitis, Ankylosing;
Uveitis
More Information:
Definitions related to adalimumab:
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A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. It is used in the treatment of RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS; CROHN'S DISEASE and ULCERATIVE COLITIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.NCI ThesaurusU.S. National Cancer Institute, 2021
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