Immunologic Factor
adalimumab
Brand Names:
Humira
Effect:
Immunologic Activity Alteration
May Treat:
Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Hidradenitis Suppurativa; Spondylitis, Ankylosing; Uveitis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to adalimumab:
  • A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. It is used in the treatment of RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS; CROHN'S DISEASE and ULCERATIVE COLITIS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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