Immunologic Factor
ipilimumab Audio
[ ih-pih-lih-myoo-mab ]
Brand Names:
Yervoy
Effect:
Increased T Lymphocyte Activation
May Treat:
Melanoma
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to ipilimumab:
  • A monoclonal antibody being studied in the treatment of certain types of cancer. Ipilimumab is made in the laboratory and binds to the molecule CTLA-4 on T cells (a type of white blood cell). Ipilimumab may block CTLA-4 and help the immune system kill cancer cells.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An anti-CTLA-4 ANTIGEN monoclonal antibody initially indicated for the treatment of certain types of metastatic MELANOMA. Its mode of actions may include blocking of CTLA-4 mediated inhibition of CYTOTOXIC T LYMPHOCYTES, allowing for more efficient destruction of target tumor cells.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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