Pharmacologic Substance
allopurinol
al·lo·pu·ri·nol [ al-uh-pyoo r-uh-nawl, -nol ]
Brand Names:
Aloprim; Duzallo; Zyloprim
Effect:
Decreased Uric Acid Synthesis
May Prevent:
Calculi; Gout; Tumor Lysis Syndrome
May Treat:
Gout
More Information:
Definitions related to allopurinol:
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A drug that lowers high levels of uric acid (a byproduct of metabolism) in the blood caused by some cancer treatments.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Drug used to treat gout and other conditions in which there is an excessive buildup of uric acid.CRISP ThesaurusNational Institutes of Health, 2006
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Allopurinol, drug used in the treatment of gout, a disease that is characterized by severe inflammation in one or more of the joints of the extremities. Allopurinol inhibits an enzyme that is necessary to form uric acid, a substance present in abnormally large amounts in the blood of persons with...Encyclopedia Britannica, Inc., 2020
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