Pharmacologic Substance
thioguanine Audio
[ thy-oh-gwah-neen ]
Brand Names:
Tabloid
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Leukemia, Basophilic, Acute; Leukemia, Eosinophilic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Neutrophilic, Chronic; Psoriasis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to thioguanine:
  • A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An anticancer drug that belongs to the family of drugs called antimetabolites.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.