Pharmacologic Substance
amiloride
[ uh-mil-uh-rahyd ]
Brand Names:
Midamor
Effect:
Decreased Blood Pressure; Decreased Collecting Duct K+ Excretion; Decreased Distal Tubule K+ Excretion; Decreased Renal Ca++ Excretion; Increased Collecting Duct Na+ Excretion; Increased Distal Tubule Na+ Excretion; Increased Renal Mg++ Excretion
May Prevent:
Hypokalemia
May Treat:
Ascites; Cystic Fibrosis; Edema; Heart Failure; Hypertension; Hypokalemia; Polyuria
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to amiloride:
  • A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.
    NCI
    U.S. National Cancer Institute, 2021
  • Pyrazine compound inhibiting sodium reabsorbtion through sodium channels in renal epithelial cells; used in conjunction with diuretics to spare potassium loss.
    CRISP Thesaurus
    National Institutes of Health, 2006
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.