Pharmacologic Substance
pyrazinamide
[ pir-uh-zin-uh-mahyd, -mid ]
Brand Names:
Rifater
Effect:
Unknown Physiological Effect
May Prevent:
Tuberculosis
May Treat:
Tuberculosis
More Information:
Definitions related to pyrazinamide:
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A pyrazine that is used therapeutically as an antitubercular agent.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Antibacterial derived from nicotinic acid, used as a tuberculostatic.CRISP ThesaurusNational Institutes of Health, 2006
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