Antibiotic
anthramycin
Subclass of:
Heterocyclic Compounds, 3-Ring; Benzodiazepinones
Definitions related to anthramycin:
  • A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans. Anthramycin binds covalently to guanine in the minor groove of DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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