Pharmacologic Substance
flumazenil
Effect:
Decreased GABA Activity
May Prevent:
Drug-Related Side Effects and Adverse Reactions
May Treat:
Drug Overdose;
Drug-Related Side Effects and Adverse Reactions
More Information:
Definitions related to flumazenil:
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A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner.NCI ThesaurusU.S. National Cancer Institute, 2021
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