Pharmacologic Substance
antithrombin
Subclass of:
Serine Proteinase Inhibitors; Anticoagulants
Definitions related to antithrombins:
  • Endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin; includes fibrin and antithrombin III.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • (direct thrombin inhibitor) Any agent that directly binds to and inactivates thrombin (factor IIa), with anticoagulant activity.
    NCI
    U.S. National Cancer Institute, 2021
  • Antithrombin (AT), an anticlotting substance occurring in the plasma of blood that functions primarily to block the action of thrombin, an enzyme central to coagulation--the process by which a clot is formed. AT combines with thrombin as well as most of the other activated blood-clotting proteins...
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2025
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