Pharmacologic Substance
estramustine Audio
[ es-truh-mus-teen ]
Brand Names:
Emcyt
Effect:
Decreased Testosterone Secretion; Increased Ovarian Estrogen Secretion
May Treat:
Prostatic Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to estramustine:
  • A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.