Pharmacologic Substance
mechlorethamine
[ me-klawr-eth-uh-meen, -klohr- ]
Brand Names:
Mustargen; Valchlor
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Hodgkin Disease; Mycosis Fungoides; Neoplasm Metastasis; Pleural Effusion, Malignant
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to mechlorethamine:
  • (nitrogen mustard hn-3) The nitrogen mustard vesicant HN-2.
    CDISC Terminology
    Clinical Data Interchange Standards Consortium (CDISC), 2021
  • A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • Antineoplastic cytotoxic alkylating agent of the nitrogen mustard group.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • (nitrogen mustard) Group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen; formerly used as toxicants and vesicants, but now used therapeutically as antineoplastic agents; they are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.