Pharmacologic Substance
bumetanide
Brand Names:
Bumex
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Increased Loop of Henle Ca++ Excretion; Increased Loop of Henle Cl- Excretion; Increased Loop of Henle K+ Excretion; Increased Loop of Henle Mg++ Excretion; Increased Loop of Henle Na+ Excretion
May Treat:
Acute Kidney Injury; Ascites; Edema; Heart Failure; Hypertension; Kidney Failure, Chronic; Liver Cirrhosis; Nephrotic Syndrome; Pulmonary Edema
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to bumetanide:
  • 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
    NCI
    U.S. National Cancer Institute, 2021
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