Pharmacologic Substance
metolazone
[ me-toh-luh-zohn ]
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Increased Distal Tubule Cl- Excretion; Increased Distal Tubule H+ Excretion; Increased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion; Increased Diuresis
May Treat:
Edema; Heart Failure; Hypertension; Nephrotic Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to metolazone:
  • A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water.
    NCI
    U.S. National Cancer Institute, 2021
  • A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.