Cell or Molecular Dysfunction
chromosomal instability
chro·mo·so·mal in·sta·bil·i·ty
Subclass of:
Chromosome Aberrations; Genomic Instability
Definitions related to chromosomal instability:
  • An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • The instability of chromosomes is attributed to the continuous formation of novel chromosome mutations. These mutations form at an elevated rate in comparison to the normal cell population. The increased frequency of structural chromosome aberrations can be caused by an abnormally high incidence of DNA double-strand breaks and translocations. Screening for chromosomal breakage and rearrangement is used as a diagnostic tool in Fanconi anemia.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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