Acquired Abnormality
isochromosomes
Subclass of:
Chromosome Aberrations; Chromosomes
Definitions related to isochromosomes:
  • An abnormal chromosome with identical arms, formed by transverse splitting of the centromere during chromosomal replication.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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