Cell or Molecular Dysfunction
chromosome breakage
[ kroh-muh-sohm brey-kij ]
Subclass of:
Chromosome Aberrations; DNA Breaks
Definitions related to chromosome breakage:
  • A structural chromosomal abnormality caused by the spontaneous or induced breakage of a chromosome. It may result in DNA sequence deletions, chromosomal translocations, or chromosomal inversions.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2021
  • Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.