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What is chronic myelogenous leukemia?
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Chronic Myeloid Leukemia
Merck Manuals
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Chronic Myelogenous Leukemia
Paul Bolin
Related terms:
primary myelofibrosis
leukemoid reaction
polycythemia vera
granulocytic sarcoma
thrombocytosis
Neoplastic Process
chronic myelogenous leukemia Audio
[ krah-nik my-eh-lah-jeh-nus loo-kee-mee-uh ]
Also called:
Chronic Myelocytic Leukemia; Chronic Myeloid Leukemia; Chronic granulocytic leukemia; Chronic myelogenous leukemia; CML
Definitions related to myeloid leukemia, chronic:
  • (chronic myeloid leukemia) Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job: White blood cells help your body fight infection; Red blood cells deliver oxygen from your lungs to your tissues and organs; Platelets help form clots to stop bleeding. When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work.
    MedlinePlus
    U.S. National Library of Medicine, 2025
  • (chronic myeloid leukemia) Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job: White blood cells help your body fight infection; Red blood cells deliver oxygen from your lungs to your tissues and organs; Platelets help form clots to stop bleeding. When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work.
    MedlinePlus Genetics
    U.S. National Library of Medicine, 2021
  • (chronic myelogenous leukemia) Chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Chronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes. Initially asymptomatic, CML progression is insidious, with a nonspecific �benign� stage (malaise, anorexia, weight loss) eventually...
    Merck Manuals
    Merck & Co., Inc., 2025
  • Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. It accounts for 20% of all leukemias affecting adults.
    Medscape
    WebMD, 2025
  • Chronic myelogenous leukemia (CML) is an uncommon type of cancer of the bone marrow - the spongy tissue inside bones where blood cells are made. CML causes an increased number of white blood cells in the blood.
    Mayo Clinic
    Mayo Foundation for Medical Education and Research, 2025
  • Chronic myeloid leukaemia (CML) is the most common myeloproliferative disorder accounting for 15-20% of all leukaemia cases.
    NIH Genetic and Rare Diseases
    National Center for Advancing Translational Sciences
  • Chronic myelogenous leukemia (CML) is a malignant clonal disorder of the hematopoietic stem cell that results in marked myeloid hyperplasia of the bone marrow. Dysregulation of hematopoiesis arises due to a BCR-ABL fusion gene that causes an abnormal expansion of myeloid cells in the bone marrow and peripheral blood. The "chronic phase"...
    Epocrates
    Athenahealth, Inc., 2019
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