Pharmacologic Substance
cobicistat
Brand Names:
Evotaz; Genvoya; Prezcobix; Stribild; Symtuza; Tybost
May Treat:
HIV Infections
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to cobicistat:
  • A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A cytochrome P450 3A (CYP3A) inhibitor that can be used to enhance the pharmacokinetic profile of certain anti-HIV-1 agents. Upon administration, cobicistat inhibits the liver enzyme CYP3A4 and limits the breakdown of co-administered agents that are metabolized by CYP3A4, and increases the concentration, systemic exposure and efficacy of the co-administered agent.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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