Disease or Syndrome
CREST syndrome
[ krest sin-drohm, -druhm ]
Subclass of:
Esophageal motility disorders;
Scleroderma, Limited;
Raynaud Disease;
Telangiectasis;
Calcinosis
Definitions related to crest syndrome:
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A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A variant of systemic sclerosis characterized by calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.NCI ThesaurusU.S. National Cancer Institute, 2021
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(limited cutaneous systemic sclerosis) A variant of systemic scleroderma characterized by features such as calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome is a member of the heterogeneous group of sclerodermas, and its name is an acronym for the cardinal clinical features of the syndrome. In 1910, Thibierge and Weissenbach described the first case report of what was later called CRST...WebMD, 2019
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Limited cutaneous systemic sclerosis is a subtype of systemic sclerosis characterized by the association of Raynaud's phenomenon and skin fibrosis on the hands, face, feet and forearms. The exact cause of limited cutaneous systemic sclerosis is unknown, but likely originates from an autoimmune reaction which leads to overproduction of...National Center for Advancing Translational Sciences
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Systemic sclerosis (a type of scleroderma) is an autoimmune connective tissue disease characterized by the production of autoantibodies (e.g., antinuclear antibody, anticentromere antibody, and antitopoisomerase I antibody) and the overproduction of collagen, which causes fibrosis of the skin and organs as well as vasculopathy with...Athenahealth, Inc., 2019
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