Pharmacologic Substance
duloxetine hydrochloride
[ duh-lok-suh-teen hy-droh-klor-ide ]
Effect:
Increased Central Nervous System Norepinephrine Activity; Increased Central Nervous System Serotonin Activity
May Treat:
Anxiety Disorders;
Depressive Disorder, Major;
Diabetic Neuropathies;
Musculoskeletal Pain
More Information:
Definitions related to duloxetine hydrochloride:
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A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes. It is also being studied in the treatment of peripheral neuropathy caused by certain anticancer drugs. Duloxetine hydrochloride increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors.NCI ThesaurusU.S. National Cancer Institute, 2021
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