Antibiotic
erythromycin estolate
Effect:
Decreased Protein Synthesis
May Treat:
Acne Vulgaris;
Campylobacter Infections;
Chancroid;
Chlamydia Infections;
Erythrasma;
Eye Infections, Bacterial;
Gastroenteritis;
Gonorrhea;
Legionnaires' Disease;
Mycoplasma Infections;
Staphylococcal Infections;
Streptococcal Infections;
Syphilis;
Urethritis;
Whooping Cough
Definitions related to erythromycin estolate:
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A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The lauryl sulfate ester of propionyl erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin estolate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin estolate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.NCI ThesaurusU.S. National Cancer Institute, 2021
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