Pharmacologic Substance
lorazepam Audio
lor·az·e·pam [ law-raz-uh-pam, luh- ]
Brand Names:
Ativan; Loreev
Effect:
Increased Central Nervous System GABA Activity
May Treat:
Anxiety Disorders; Catatonia; Depressive Disorder; Epilepsies, Partial; Psychotic Disorders; Sleep Initiation and Maintenance Disorders; Status Epilepticus; Substance Withdrawal Syndrome; Vomiting
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to lorazepam:
  • 7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.
    NCI
    U.S. National Cancer Institute, 2021
  • A drug that is used to treat anxiety and certain seizure disorders (such as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs to the families of drugs called antiemetics and benzodiazepines.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.