Pharmacologic Substance
flumazenil
Effect:
Decreased GABA Activity
May Prevent:
Drug-Related Side Effects and Adverse Reactions
May Treat:
Drug Overdose; Drug-Related Side Effects and Adverse Reactions
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to flumazenil:
  • A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.