Pharmacologic Substance
fluocinolone acetonide
Effect:
Antipruritic Activity; Decreased Immunologically Active Molecule Activity; Decreased Protein Synthesis; Vasoconstriction
May Treat:
Dermatitis, Atopic;
Facial Dermatoses;
Foot Dermatoses;
Hand Dermatoses;
Inflammation;
Leg Dermatoses;
Pruritus;
Psoriasis;
Scalp Dermatoses
More Information:
Definitions related to fluocinolone acetonide:
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A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow.NCI ThesaurusU.S. National Cancer Institute, 2021
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