A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.

A condition marked by increased levels of uric acid in the blood, joints, and tissue. The buildup of uric acid in the joints and tissues causes arthritis and inflammation.

A form of arthritis that occurs when uric acid builds up in the joints; The big toe, knee, and ankle joints are most often affected.

Gout is a common type of inflammatory arthritis. It causes pain, swelling, and redness in one or more joints. It usually happens as a flare, which can last for a week or two and then gets better. The flares often begin in your big toe or a lower limb. Gout happens when too much uric acid (urate) builds up in your body over a long time. Uric acid is a waste product your body makes when it breaks down purines. Purines are substances that are in your body's tissues and in many foods. When your body breaks down old cells or digests foods that contain purine, most of the uric acid that's made dissolves in your blood. Your kidneys filter the uric acid out of your blood, and it leaves your body in your urine (pee). However, sometimes your body can make too much uric acid or does not remove enough of it. Then the uric acid levels build up in your body, including in your blood. Having too much uric acid in the blood is called hyperuricemia. It does not cause health problems for everyone. But in some people, uric acid forms needle-like crystals. They can form in your joints, which causes gout. The crystals can also cause kidney stones. Calcium pyrophosphate arthritis, sometimes called pseudogout, is a related disease. It causes similar symptoms and is sometimes confused with gout. But it is caused by a buildup of calcium phosphate, not uric acid. Many people develop gout. You are more likely to get it if you: Are male.; Are older; it usually develops in middle age.; Have obesity.; Have certain health conditions, such as: Heart failure; High blood pressure; Metabolic syndrome; Chronic kidney disease; Conditions that cause your cells to break down more quickly, such as psoriasis or some cancers; Rare genetic conditions that lead to increased uric acid.; Have a family history of gout.; Have an unhealthy diet and eat foods that are rich in purines, such as red meat, organ meats, certain seafoods.; Drink alcohol.; Eat and drink lots of foods and beverages that contain fructose (a type of sugar).; Take certain medicines, such as diuretics (water pills), low-dose aspirin, and some medicines that weaken your immune system.; Take high amounts of niacin (vitamin B-3). Gout usually happens in only one joint at a time. It is often found in the big toe, but can also affect other joints, including your other toes, ankle, and knee. Gout flares often start suddenly at night, and the symptoms in the affected joint often include: Intense pain, which may be bad enough to wake you up; Swelling; Redness; Warmth. The flares typically get better within a week or two. In between flares, you usually don't have symptoms. Some people may have flares often, while others may not have another flare for years. But over time, if left untreated, your flares may happen more often and last longer. And if gout is untreated over long periods of time, you can develop tophi. Tophi are hard, uric acid deposits under the skin. They start out as painless, but over time, they can become painful. They can also cause bone and soft tissue damage and misshapen joints. To find out if you have gout, your health care provider: Will take your medical history, which includes asking about your symptoms.; Will do a physical exam, including examining the affected joint(s).; May order various tests, such as: A test of a sample of fluid from one of your painful joints. The fluid is examined under a microscope and is checked for uric acid crystals.; A uric acid blood or urine test.; An ultrasound or special CT scan to look for uric acid crystal buildup in the affected joint and check for other conditions that may be causing the symptoms. . There are effective treatments for gout. Which treatment you get will depend on your symptoms and the cause of your gout. The goals of your treatment will be...

Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.

Metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of URIC ACID calculi.

Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues.

Gout is a disorder caused by hyperuricemia (serum urate > 6.8 mg/dL [> 0.4 mmol/L]) that results in the precipitation of monosodium urate crystals in and around joints, most often causing recurrent acute or chronic arthritis. The initial attack (flare) of gout is usually monarticular and often involves the 1st metatarsophalangeal joint....

Gout is a common and complex form of arthritis that can affect anyone. It's characterized by sudden, severe attacks of pain, swelling, redness and tenderness in the joints, often the joint at the base of the big toe.

Gout is a syndrome characterized by: hyperuricemia and deposition of urate crystals causing attacks of acute inflammatory arthritis; tophi around the joints and possible joint destruction; renal glomerular, tubular, and interstitial disease; and uric acid urolithiasis. The disease most commonly affects the first toe (podagra), foot,...

Gout, metabolic disorder characterized by recurrent acute attacks of severe inflammation in one or more of the joints of the extremities. Gout results from the deposition, in and around the joints, of uric acid salts, which are excessive throughout the body in persons with the disorder. Uric acid...