Pharmacologic Substance
itraconazole Audio
[ ih-truh-kah-nuh-zole ]
Brand Names:
Onmel; Sporanox; Tolsura
Effect:
Decreased Cell Wall Integrity
May Prevent:
AIDS-Related Opportunistic Infections
May Treat:
AIDS-Related Opportunistic Infections; Aspergillosis; Blastomycosis; Candidiasis, Chronic Mucocutaneous; Candidiasis, Oral; Candidiasis, Vulvovaginal; Coccidioidomycosis; Cryptococcosis; Histoplasmosis; Leishmaniasis; Neutropenia; Onychomycosis; Paracoccidioidomycosis; Sporotrichosis; Zygomycosis
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to itraconazole:
  • A drug used to prevent or treat fungal infections. It belongs to the family of drugs called antifungal agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Orally active antimycotic; structurally related to ketoconazole.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.