Pharmacologic Substance
loperamide Audio
lo·per·a·mide [ loh-per-uh-mahyd ]
Brand Names:
Diamode; Imodium; Imodium Advanced; Imodium Multi-Symptom Relief
Effect:
Decreased GI Motility; Stimulation Large Intestine Fluid/Electrolyte Absorption; Stimulation Small Intestine Fluid/Electrolyte Absorption
May Treat:
Colonic Diseases, Functional; Diarrhea; Dysentery, Bacillary
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to loperamide:
  • A synthetic agent chemically related to the opiates with anti-diarrheal properties. Loperamide decreases gastro-intestinal motility by effects on the circular and longitudinal muscles of the intestine. Part of its anti-diarrheal effect may be due to a reduction of gastro-intestinal secretion produced by opioid receptor binding in the intestinal mucosa. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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