Pharmacologic Substance
midomafetamine
Subclass of:
Amphetamines
Also called:
Methylenedioxymethamphetamine (MDMA); Ecstasy
Definitions related to midomafetamine:
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(3,4-methylenedioxymethamphetamine) A ring-substituted amphetamine derivative, structurally related to the hallucinogen mescaline, with entactogenic, neurotoxic, and motor-stimulatory activities. 3,4-methylenedioxymethamphetamine (MDMA) produces an acute, rapid enhancement in both the release of serotonin from and the inhibition of serotonin reuptake by serotonergic nerve endings in the brain. Once within the cell, MDMA depletes stores of tryptophan hydroxylase (TPH) via acute oxidative inactivation; in turn, depleted stores of TPH leave cell terminals open to damage from oxidative stress, possibly a source of MDMA neurotoxicity. This agent also induces norepinephrine, dopamine, and acetylcholine release and can act directly on a number of receptors, including alpha 2-adrenergic and 5-hydroxytryptamine (5-HT) 2A receptors. MDMA may suppress the dyskinesia associated with long-term use of L-dopamine (L-DOPA) without affecting the efficacy of L-DOPA treatment.NCI ThesaurusU.S. National Cancer Institute, 2021
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(3,4 methylenedioxymethamphetamine) Synthetic adrenergic agonist resembling both amphetamine (a stimulant) and mescaline (a hallucinogen); "designer drug" once touted as potentially psychotherapeutic, but now a controlled substance considered a drug of abuse.CRISP ThesaurusNational Institutes of Health, 2006
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(n-methyl-3,4-methylenedioxyamphetamine) An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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MDMA (3,4-methylenedioxymethamphetamine) is an amphetamine analog with stimulant and hallucinogenic effects.Merck & Co., Inc., 2020
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Ecstasy, MDMA (3,4, Methylenedioxymethamphetamine), a euphoria-inducing stimulant and hallucinogen. The use of Ecstasy, commonly known as "E," has been widespread despite the drug's having been banned worldwide in 1985 by its addition to the international Convention on Psychotropic Substances. It...Encyclopedia Britannica, Inc., 2020
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