Disease or Syndrome
periventricular leukomalacia
Subclass of:
Infant, Premature, Diseases;
Cerebrovascular Disorders;
Encephalomalacia
Definitions related to leukomalacia, periventricular:
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(periventricular leukomalacia) A form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles, that may evolve into focal cysts.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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(periventricular leukomalacia) A rare neurologic condition characterized by focal periventricular necrosis and diffuse cerebral white matter injury. It most commonly occurs in premature infants. Signs of brain damage typically begin to show in early childhood. Long-term outcomes depend on the extent of the white matter injury and include cognitive delay, motor delay, vision and hearing impairment, and cerebral palsy.OrphaNetINSERM, 2021
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(periventricular leukomalacia) Necrosis and softening of the white matter around the ventricles in the brain. It is usually seen in preterm infants and caused by lack of blood flow and oxygenation in the periventricular brain parenchyma.NCI ThesaurusU.S. National Cancer Institute, 2021
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Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Periventricular leukomalacia (PVL) is a brain injury disorder characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles...National Center for Advancing Translational Sciences
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