Pharmacologic Substance
pyrimethamine Audio
py·ri·meth·a·mine [ pahy-ruh-meth-uh-meen, -min ]
Brand Names:
Daraprim; Rebalance
May Prevent:
Malaria
May Treat:
AIDS-Related Opportunistic Infections; Malaria, Falciparum; Toxoplasmosis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to pyrimethamine:
  • A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.