Antibiotic
trimethoprim Audio
tri·meth·o·prim [ trahy-meth-uh-prim ]
Brand Names:
Bactrim; Equisul SDT; Polytrim; Primsol; Sulfatrim; Uniprim
Effect:
Increased Cellular Death
May Treat:
AIDS-Related Opportunistic Infections; Bronchitis; Escherichia coli Infections; Eye Infections, Bacterial; Klebsiella Infections; Pneumonia, Pneumocystis; Proteus Infections; Staphylococcal Infections; Toxoplasmosis; Urinary Tract Infections
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to trimethoprim:
  • A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and antiprotozoal properties. As a pyrimidine inhibitor of bacterial dihydrofolate reductase, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid. The antibacterial activity of this agent is potentiated by sulfonamides. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • Antibacterial used in combination with a sulfonamide to treat some urinary tract infections and pneumocystis pneumonia, and alone as an antimalarial.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.