A disorder of defective chondrocyte differentiation and mineralization of the epiphyseal plate due to deficiency of calcium, phosphate, or vitamin D. Rickets can manifest clinically with features such as craniotabes, costrochondral junction enlargement, widening of the wrists and ankles, lower extremity bowing, and failure to thrive. This condition is diagnosed radiographically, and is characterized by growth plate widening as well as metaphyseal cupping and fraying.

Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities.

Disorder of calcium and phosphorus metabolism affecting bony structures, due to a variety of defects in vitamin D, calcium, and phosphorous homeostasis, including dietary deficiencies or malabsorption.

Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.

Rickets causes soft, weak bones in children. It usually occurs when they do not get enough vitamin D, which helps growing bones absorb the minerals calcium and phosphorous. It can also happen when calcium or phosphorus levels are too low. Your child might not get enough vitamin D if he or she Has dark skin; Spends too little time outside; Has on sunscreen all the time when out of doors; Doesn't eat foods containing vitamin D because of lactose intolerance or a strict vegetarian diet; Is breastfed without receiving vitamin D supplements; Can't make or use vitamin D because of a medical disorder such as celiac disease. In addition to dietary rickets, children can get an inherited form of the disease. Symptoms include bone pain or tenderness, impaired growth, and deformities of the bones and teeth. Your child's doctor uses lab and imaging tests to make the diagnosis. Treatment is replacing the calcium, phosphorus, or vitamin D that are lacking in the diet. Rickets is rare in the United States.

Rickets is divided into two major categories including calcipenic and phosphopenic. Hypophosphatemia is described as a common manifestation of both categories. Hypophosphatemic rickets is the most common type of rickets that is characterized by low levels of serum phosphate, resistance to ultraviolet radiation or vitamin D intake. There are several issues involved in hypophosphatemic rickets such as calcium, vitamin D, phosphorus deficiencies. Moreover, other disorder can be associated with its occurrence such as absorption defects due to pancreatic, intestinal, gastric, and renal disorders and hepatobiliary disease. Symptoms are usually seen in childhood and can be varied in severity. Severe forms may be linked to bowing of the legs, poor bone growth, and short stature as well as joint and bone pain. Hypophosphatemic rickets are associated with renal excretion of phosphate, hypophosphatemia, and mineral defects in bones. The familial type of the disease is the most common type of rickets.

Rickets is a disease of growing bone that is unique to children and adolescents. It is caused by a failure of osteoid to calcify in a growing person.

Rickets is the softening and weakening of bones in children, usually because of an extreme and prolonged vitamin D deficiency. Rare inherited problems also can cause rickets.

Rickets is a condition that causes children to have soft, weak bones. It usually occurs when children do not get enough vitamin D, which helps growing bones absorb important nutrients. Vitamin D comes from sunlight and food. Skin produces vitamin D in response to the sun's rays. Some foods also contain vitamin D, including fortified...

Rickets refers to changes caused by deficient mineralization at the growth plate of long bones. Osteomalacia refers to impaired mineralization of the bone matrix. Rickets and osteomalacia usually occur together while the growth plates are open. Osteomalacia can also occur after the growth plates have fused. Rickets can manifest in...

Rickets, disease of infancy and childhood characterized by softening of the bones, leading to abnormal bone growth and caused by a lack of vitamin D in the body. When the disorder occurs in adults, it is known as osteomalacia. Vitamin D (or, more specifically, calcitriol) is a steroid hormone that...