Antibiotic
streptomycin
strep·to·my·cin [ strep-tuh-mahy-sin ]
Effect:
Decreased Protein Synthesis
May Treat:
Brucellosis;
Chancroid;
Endocarditis, Bacterial;
Escherichia coli Infections;
Granuloma Inguinale;
Klebsiella Infections;
Mycobacterium Infections;
Plague;
Proteus Infections;
Streptococcal Infections;
Tularemia;
Urinary Tract Infections
More Information:
Definitions related to streptomycin:
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An aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, streptomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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First of the aminoglycoside antibiotics to be isolated; derived from Streptomyces griseus.CRISP ThesaurusNational Institutes of Health, 2006
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Streptomycin, antibiotic synthesized by the soil organism Streptomyces griseus. Streptomycin was discovered by American biochemists Selman Waksman, Albert Schatz, and Elizabeth Bugie in 1943. The drug acts by interfering with the ability of a microorganism to synthesize certain vital proteins. It...Encyclopedia Britannica, Inc., 2020
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