Pharmacologic Substance
sulfisoxazole
[ suhl-fi-sok-suh-zohl ]
Effect:
Cellular Growth Phase Arrest; Cellular Synthetic Activity Alteration; Decreased Folic Acid Modification
May Treat:
Chlamydia Infections;
Nocardia Infections;
Otitis Media;
Respiratory Tract Fistula;
Urinary Tract Infections
More Information:
Definitions related to sulfisoxazole:
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A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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