Pharmacologic Substance
tinidazole

[ ty-nih-duh-zole ]
Brand Names:
Tindamax
Effect:
Decreased Protein Synthesis; DNA Integrity Alteration; Increased Cellular Death
May Treat:
Amebiasis;
Giardiasis;
Vaginosis, Bacterial
More Information:
Definitions related to tinidazole:
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A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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