Pharmacologic Substance
valsartan
Brand Names:
Byvalson; Diovan; Diovan HCT; Entresto; Exforge; Exforge HCT
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Treat:
Diabetic Nephropathies; Heart Failure; Hypertension; Ventricular Dysfunction, Left
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to valsartan:
  • A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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