Pharmacologic Substance
floxuridine Audio
[ flox-yoor-ih-deen ]
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Colorectal Neoplasms; Stomach Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to floxuridine:
  • A drug used in the treatment of cancer. It is a type of antimetabolite.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
    CRISP Thesaurus
    National Institutes of Health, 2006
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