Pharmacologic Substance
tolnaftate
[ tawl-naf-teyt, tol- ]
Brand Names:
Absorbine Jr. Antifungal; Blis-To-Sol; Cidacin; Clarus; Footshield Plus; FungaBlend; Fungifoam; Fungi-Gone; Fungi-Guard; Fungi-Nail Reformulated Mar 2019; Fungoid-D; hiVETIC; Hongo Cura; Hongo Killer Antifungal; Lamisil Defense; Mycocide NS; Ongo-Fin; Proclearz; Tinactin; Tinaderm; Ting; Tolcylen
Effect:
Cellular Growth Phase Arrest
May Treat:
Tinea Pedis; Tinea Versicolor
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to tolnaftate:
  • A synthetic antifungal agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.
    NCI
    U.S. National Cancer Institute, 2021
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