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Nature Sep 2021Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has...
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently and the main underlying mechanism proposed is the chemical transformation of drugs by microorganisms (biotransformation). Here we investigated the depletion of 15 structurally diverse drugs by 25 representative strains of gut bacteria. This revealed 70 bacteria-drug interactions, 29 of which had not to our knowledge been reported before. Over half of the new interactions can be ascribed to bioaccumulation; that is, bacteria storing the drug intracellularly without chemically modifying it, and in most cases without the growth of the bacteria being affected. As a case in point, we studied the molecular basis of bioaccumulation of the widely used antidepressant duloxetine by using click chemistry, thermal proteome profiling and metabolomics. We find that duloxetine binds to several metabolic enzymes and changes the metabolite secretion of the respective bacteria. When tested in a defined microbial community of accumulators and non-accumulators, duloxetine markedly altered the composition of the community through metabolic cross-feeding. We further validated our findings in an animal model, showing that bioaccumulating bacteria attenuate the behavioural response of Caenorhabditis elegans to duloxetine. Together, our results show that bioaccumulation by gut bacteria may be a common mechanism that alters drug availability and bacterial metabolism, with implications for microbiota composition, pharmacokinetics, side effects and drug responses, probably in an individual manner.
Topics: Animals; Antidepressive Agents; Bacteria; Bioaccumulation; Caenorhabditis elegans; Cells; Click Chemistry; Duloxetine Hydrochloride; Gastrointestinal Microbiome; Humans; Metabolomics; Models, Animal; Proteomics; Reproducibility of Results
PubMed: 34497420
DOI: 10.1038/s41586-021-03891-8 -
Toxics Dec 2022Chlorinated paraffins (CPs), a class of persistent, toxic, and bioaccumulated compounds, have received increasing attention for their environmental occurrence and... (Review)
Review
Chlorinated paraffins (CPs), a class of persistent, toxic, and bioaccumulated compounds, have received increasing attention for their environmental occurrence and ecological and human health risks worldwide in the past decades. Understanding the environmental behavior and fate of CPs faces a huge challenge owing to the extremely complex CP congeners. Consequently, the aims of the present study are to summarize and integrate the bioaccumulation and biotransformation of CPs, including the occurrence of CPs in biota, tissue distribution, biomagnification, and trophic transfer, and biotransformation of CPs in plants, invertebrates, and vertebrates in detail. Biota samples collected in China showed higher CP concentrations than other regions, which is consistent with their huge production and usage. The lipid content is the major factor that determines the physical burden of CPs in tissues or organs. Regarding the bioaccumulation of CPs and their influence factors, inconsistent results were obtained. Biotransformation is an important reason for this variable. Some CP congeners are readily biodegradable in plants, animals, and microorganisms. Hydroxylation, dechlorination, chlorine rearrangement, and carbon chain decomposition are potential biotransformation pathways for the CP congeners. Knowledge of the influence of chain length, chlorination degree, constitution, and stereochemistry on the tissue distribution, bioaccumulation, and biotransformation is still scarce.
PubMed: 36548610
DOI: 10.3390/toxics10120778 -
Environment International May 2022Arsenic exists universally in freshwater and marine environments, threatening the survival of aquatic organisms and human health. To elucidate arsenic bioaccumulation... (Review)
Review
Arsenic exists universally in freshwater and marine environments, threatening the survival of aquatic organisms and human health. To elucidate arsenic bioaccumulation and biotransformation processes in aquatic organisms, this review evaluates the dissolved uptake, dietary assimilation, biotransformation, and elimination of arsenic in aquatic organisms and discusses the major factors influencing these processes. Environmental factors such as phosphorus concentration, pH, salinity, and dissolved organic matter influence arsenic absorption from aquatic systems, whereas ingestion rate, gut passage time, and gut environment affect the assimilation of arsenic from foodstuffs. Arsenic bioaccumulation and biotransformation mechanisms differ depending on specific arsenic species and the involved aquatic organism. Although some enzymes engaged in arsenic biotransformation are known, deciphering the complicated synthesis and degradation pathway of arsenobetaine remains a challenge. The elimination of arsenic involves many processes, such as fecal excretion, renal elimination, molting, and reproductive processes. This review facilitates our understanding of the environmental behavior and biological fate of arsenic and contributes to regulation of the environmental risk posed by arsenic pollution.
Topics: Aquatic Organisms; Arsenic; Bioaccumulation; Biotransformation; Humans; Water Pollutants, Chemical
PubMed: 35378441
DOI: 10.1016/j.envint.2022.107221 -
Toxics Nov 2023Plastics, including microplastics, have generally been regarded as harmful to organisms because of their physical characteristics. There has recently been a call to... (Review)
Review
Plastics, including microplastics, have generally been regarded as harmful to organisms because of their physical characteristics. There has recently been a call to understand and regard them as persistent, bioaccumulative, and toxic. This review elaborates on the reasons that microplastics in particular should be considered as "toxic pollutants". This view is supported by research demonstrating that they contain toxic chemicals within their structure and also adsorb additional chemicals, including polychlorinated biphenyls (PCBs), pesticides, metals, and polycyclic aromatic hydrocarbons (PAHs), from the environment. Furthermore, these chemicals can be released into tissues of animals that consume microplastics and can be responsible for the harmful effects observed on biological processes such as development, physiology, gene expression, and behavior. Leachates, weathering, and biofilm play important roles in the interactions between microplastics and biota. Global policy efforts by the United Nations Environmental Assembly via the international legally binding treaty to address global plastic pollution should consider the designation of harmful plastics (e.g., microplastics) with associated hazardous chemicals as toxic pollutants.
PubMed: 37999586
DOI: 10.3390/toxics11110935 -
Environment International Jan 2022Per- and polyfluoroalkyl substances (PFASs) are artificial persistent organic pollutants ubiquitous in ecosystem, and their bioaccumulation and adverse outcomes in... (Review)
Review
Per- and polyfluoroalkyl substances (PFASs) are artificial persistent organic pollutants ubiquitous in ecosystem, and their bioaccumulation and adverse outcomes in plants have attracted extensive concerns. Here, we review the toxic effects of PFASs encountered by various plants from physiological, biochemical and molecular perspectives. The exposure routes and bioaccumulation of PFASs in plants from contaminated sites are also summarized. The bioaccumulation of PFASs in plants from contaminated sites varied between ng/g and μg/g levels. The 50% inhibition concentration of PFASs for plant growth is often several orders of magnitude higher than the environmentally relevant concentrations (ERCs). ERCs of PFASs rarely lead to obvious phenotypic/physiological damages in plants, but markedly perturb some biological activities at biochemical and molecular scales. PFAS exposure induces the over-generated reactive oxygen species and further damages plant cell structure and organelle functions. A number of biochemical activities in plant cells are perturbed, such as photosynthesis, gene expression, protein synthesis, carbon and nitrogen metabolisms. To restore the desire states of cells exposed to PFASs, plants initiate several detoxifying mechanisms, including enzymatic antioxidants, non-enzymatic antioxidants, metallothionein genes and metabolic reprogramming. Future challenges and opportunities in PFAS phytotoxicity studies are also proposed in the review.
Topics: Bioaccumulation; Ecosystem; Fluorocarbons; Plants; Water Pollutants, Chemical
PubMed: 34592655
DOI: 10.1016/j.envint.2021.106891 -
Environmental Toxicology and Chemistry May 2022Understanding the bioaccumulation of engineered nanomaterials (ENMs) is essential for making regulatory decisions on potential environmental risks. Research in the field... (Meta-Analysis)
Meta-Analysis Review
Understanding the bioaccumulation of engineered nanomaterials (ENMs) is essential for making regulatory decisions on potential environmental risks. Research in the field of ENM bioaccumulation has increased in recent years, but the compilation and statistical analysis of the available experimental data have not been updated. We therefore performed a meta-analysis of the existing literature on the bioaccumulation of eight types of nondissolvable ENMs (titanium dioxide [TiO ], aluminum oxide [Al O ], gold [Au], fullerene [C ], carbon nanotubes, iron oxide [FeO ], graphene, and polystyrene) in nonmammalian freshwater aquatic organisms across three trophic levels including phytoplankton, zooplankton, and fish. Three typical endpoints were used to assess the bioaccumulation potential: the bioconcentration factor (BCF), the bioaccumulation factor (BAF), and the biomagnification factor (BMF). Our results suggest that zooplankton has greater mean logarithmic BCF and BAF values than phytoplankton (3.31 vs. 1.42) and fish (2.04). The ENMs are biomagnified in zooplankton, with a mean BMF of 17.4, whereas trophic transfer from primary consumers (zooplankton) to secondary consumers (fish) was not observed (mean BMF of 0.13). No clear dependency was identified between the physicochemical characteristics of ENMs (e.g., primary particle size, zeta potential, or shape) and bioaccumulation, except for coated versus uncoated particles accumulated in phytoplankton. Carbonaceous ENMs were found to be more bioaccumulated than the other ENMs we considered, except for TiO . A meta-analysis of bioaccumulation data can (1) deepen the understanding of bioconcentration, bioaccumulation, and biomagnification of ENMs, (2) be used to support grouping strategies as a basis for a safer-by-design approach for ENMs, (3) be integrated into comprehensive hazard and risk assessments, (4) promote the standardization of testing guidelines, and (5) enhance future kinetic bioaccumulation modeling. Environ Toxicol Chem 2022;41:1202-1214. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Topics: Animals; Aquatic Organisms; Bioaccumulation; Fishes; Fresh Water; Nanostructures; Nanotubes, Carbon; Phytoplankton; Water Pollutants, Chemical; Zooplankton
PubMed: 35188281
DOI: 10.1002/etc.5312 -
Toxins Aug 2020Microcystin-LR (MC-LR) is prevalent in water and can be translocated into soil-crop ecosystem via irrigation, overflow (pollution accident), and cyanobacterial manure...
Microcystin-LR (MC-LR) is prevalent in water and can be translocated into soil-crop ecosystem via irrigation, overflow (pollution accident), and cyanobacterial manure applications, threatening agricultural production and human health. However, the effects of various input pathways on the bioaccumulation and toxicity of MCs in terrestrial plants have been hardly reported so far. In the present study, pot experiments were performed to compare the bioaccumulation, toxicity, and health risk of MC-LR as well as its degradation in soils among various treatments with the same total amount of added MC-LR (150 μg/kg). The treatments included irrigation with polluted water (IPW), cultivation with polluted soil (CPS), and application of cyanobacterial manure (ACM). Three common leaf-vegetables in southern China were used in the pot experiments, including L., L., and L. All leaf vegetables could bioaccumulate MC-LR under the three treatments, with much higher MC-LR bioaccumulation, especially root bioconcentration observed in ACM treatment than IPW and CPS treatments. An opposite trend in MC-LR degradation in soils of these treatments indicated that ACM could limit MC-LR degradation in soils and thus promote its bioaccumulation in the vegetables. MC-LR bioaccumulation could cause toxicity to the vegetables, with the highest toxic effects observed in ACM treatment. Similarly, bioaccumulation of MC-LR in the edible parts of the leaf-vegetables posed 1.1~4.8 fold higher human health risks in ACM treatment than in IPW and CPS treatments. The findings of this study highlighted a great concern on applications of cyanobacterial manure.
Topics: Bacterial Toxins; Bioaccumulation; Biodegradation, Environmental; China; Crops, Agricultural; Cyanobacteria; Ecosystem; Food Contamination; Humans; Marine Toxins; Microcystins; Risk Assessment; Soil Microbiology; Vegetables
PubMed: 32823916
DOI: 10.3390/toxins12080523 -
ACS ES&T Water Apr 2023Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic compounds used in commercial applications, household products, and industrial processes. The concern...
Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic compounds used in commercial applications, household products, and industrial processes. The concern around the environmental persistence, bioaccumulation and toxicity of this vast contaminant class continues to rise. We conducted a review of the scientific literature to compare patterns of PFAS bioaccumulation in marine organisms and identify compounds of potential concern. PFAS occurrence data in seawater, sediments, and several marine taxa was analyzed from studies published between the years 2000 and 2020. Taxonomic and tissue-specific differences indicated elevated levels in protein-rich tissues and in air-breathing organisms compared to those that respire in water. Long-chain perfluoroalkyl carboxylic acids, particularly perfluoroundecanoic acid, were detected at high concentrations across several taxa and across temporal studies indicating their persistence and bioaccumulative potential. Perfluorooctanesulfonic acid was elevated in various tissue types across taxa. Precursors and replacement PFAS were detected in several marine organisms. Identification of these trends across habitats and taxa can be applied towards biomonitoring efforts, determination of high-risk taxa, and criteria development. This review also highlights challenges related to PFAS biomonitoring including (i) effects of environmental and biological variables, (ii) evaluation of protein binding sites and affinities, and (iii) biotransformation of precursors.
PubMed: 37261084
DOI: 10.1021/acsestwater.2c00296 -
PloS One 2020Microplastic (MP) contamination has been well documented across a range of habitats and for a large number of organisms in the marine environment. Consequently,... (Meta-Analysis)
Meta-Analysis
Microplastic (MP) contamination has been well documented across a range of habitats and for a large number of organisms in the marine environment. Consequently, bioaccumulation, and in particular biomagnification of MPs and associated chemical additives, are often inferred to occur in marine food webs. Presented here are the results of a systematic literature review to examine whether current, published findings support the premise that MPs and associated chemical additives bioaccumulate and biomagnify across a general marine food web. First, field and laboratory-derived contamination data on marine species were standardised by sample size from a total of 116 publications. Second, following assignment of each species to one of five main trophic levels, the average uptake of MPs and of associated chemical additives was estimated across all species within each level. These uptake data within and across the five trophic levels were then critically examined for any evidence of bioaccumulation and biomagnification. Findings corroborate previous studies that MP bioaccumulation occurs within each trophic level, while current evidence around bioaccumulation of associated chemical additives is much more ambiguous. In contrast, MP biomagnification across a general marine food web is not supported by current field observations, while results from the few laboratory studies supporting trophic transfer are hampered by using unrealistic exposure conditions. Further, a lack of both field and laboratory data precludes an examination of potential trophic transfer and biomagnification of chemical additives associated with MPs. Combined, these findings indicate that, although bioaccumulation of MPs occurs within trophic levels, no clear sign of MP biomagnification in situ was observed at the higher trophic levels. Recommendations for future studies to focus on investigating ingestion, retention and depuration rates for MPs and chemical additives under environmentally realistic conditions, and on examining the potential of multi-level trophic transfer for MPs and chemical additives have been made.
Topics: Aquatic Organisms; Bioaccumulation; Environmental Monitoring; Food Chain; Laboratories; Microplastics; Water Pollution
PubMed: 33064755
DOI: 10.1371/journal.pone.0240792 -
Trends in Ecology & Evolution May 2021Predator-prey interactions present heightened opportunities for pathogen spillover, as predators are at risk of exposure to infectious agents harbored by prey.... (Review)
Review
Predator-prey interactions present heightened opportunities for pathogen spillover, as predators are at risk of exposure to infectious agents harbored by prey. Epizootics with high morbidity and mortality have been recorded following prey-to-predator spillover events, which have had significant conservation implications for sensitive species. Using felids as a detailed case study, we have documented both virulent and clinically silent infections in apex predators following transfer of microbes from prey. We draw on these examples and others to examine the mechanisms that determine frequency and outcome of predator exposure to prey-based pathogens. We propose that predator-prey dynamics should be more thoroughly considered in empirical research and disease dynamic modeling approaches in order to reveal answers to outstanding questions relating to pathogen bioaccumulation.
Topics: Animals; Bioaccumulation; Food Chain; Population Dynamics; Predatory Behavior
PubMed: 33549372
DOI: 10.1016/j.tree.2021.01.008