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Journal of Clinical Medicine Oct 2021The recognition and management of life-threatening hemorrhage in the polytrauma patient poses several challenges to prehospital rescue personnel and hospital providers.... (Review)
Review
The recognition and management of life-threatening hemorrhage in the polytrauma patient poses several challenges to prehospital rescue personnel and hospital providers. First, identification of acute blood loss and the magnitude of lost volume after torso injury may not be readily apparent in the field. Because of the expression of highly effective physiological mechanisms that compensate for a sudden decrease in circulatory volume, a polytrauma patient with a significant blood loss may appear normal during examination by first responders. Consequently, for every polytrauma victim with a significant mechanism of injury we assume substantial blood loss has occurred and life-threatening hemorrhage is progressing until we can prove the contrary. Second, a decision to begin damage control resuscitation (DCR), a costly, highly complex, and potentially dangerous intervention must often be reached with little time and without sufficient clinical information about the intended recipient. Whether to begin DCR in the prehospital phase remains controversial. Furthermore, DCR executed imperfectly has the potential to worsen serious derangements including acidosis, coagulopathy, and profound homeostatic imbalances that DCR is designed to correct. Additionally, transfusion of large amounts of homologous blood during DCR potentially disrupts immune and inflammatory systems, which may induce severe systemic autoinflammatory disease in the aftermath of DCR. Third, controversy remains over the composition of components that are transfused during DCR. For practical reasons, unmatched liquid plasma or freeze-dried plasma is transfused now more commonly than ABO-matched fresh frozen plasma. Low-titer type O whole blood may prove safer than red cell components, although maintaining an inventory of whole blood for possible massive transfusion during DCR creates significant challenges for blood banks. Lastly, as the primary principle of management of life-threatening hemorrhage is surgical or angiographic control of bleeding, DCR must not eclipse these definitive interventions.
PubMed: 34682916
DOI: 10.3390/jcm10204793 -
Revista Medica Del Instituto Mexicano... Jan 2023In 2022, 2 years on from the start of the pandemic, the Instituto Mexicano del Seguro Social (IMSS, Mexican Institute for Social Security) has been reorganizing its...
In 2022, 2 years on from the start of the pandemic, the Instituto Mexicano del Seguro Social (IMSS, Mexican Institute for Social Security) has been reorganizing its services at full, out of which blood banks play a key role. In addition, on June 14 it is celebrated the World Blood Donor Day by the World Health Organization and this year Mexico was the host country for the celebration. Therefore, it is important to highlight the work carried out in blood banks, ranging from their main activity, which is the recruitment of blood donors and the blood components production, to the different interventions they have in the field of transplantation, diseases emerging diagnosis and the development of new therapeutic modalities, such as, for example, cell therapy.
Topics: Humans; Academies and Institutes; Blood Banks; Blood Donors; Mexico; Social Security
PubMed: 36377981
DOI: No ID Found -
Transfusion Clinique Et Biologique :... May 2024The field of haemovigilance continues to develop, building on more than forty years of international experience. This review considers the current scope and activities... (Review)
Review
The field of haemovigilance continues to develop, building on more than forty years of international experience. This review considers the current scope and activities of haemovigilance around the world and explores aspects of preparation for the advent of new blood products and alternative therapies to transfusion; new tools for data acquisition (including patient- and donor-reported outcomes, and data from 'wearables') and the analysis and communication of haemovigilance results.
Topics: Humans; Blood Safety; Blood Transfusion; Blood Banks; Blood Donors; Forecasting
PubMed: 38460837
DOI: 10.1016/j.tracli.2024.03.001 -
Metabolites Jun 2023Red blood cells (RBC) are the most abundant cell in the human body, with a central role in oxygen transport and its delivery to tissues. However, omics technologies... (Review)
Review
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in oxygen transport and its delivery to tissues. However, omics technologies recently revealed the unanticipated complexity of the RBC proteome and metabolome, paving the way for a reinterpretation of the mechanisms by which RBC metabolism regulates systems biology beyond oxygen transport. The new data and analytical tools also informed the dissection of the changes that RBCs undergo during refrigerated storage under blood bank conditions, a logistic necessity that makes >100 million units available for life-saving transfusions every year worldwide. In this narrative review, we summarize the last decade of advances in the field of RBC metabolism in vivo and in the blood bank in vitro, a narrative largely influenced by the authors' own journeys in this field. We hope that this review will stimulate further research in this interesting and medically important area or, at least, serve as a testament to our fascination with this simple, yet complex, cell.
PubMed: 37512500
DOI: 10.3390/metabo13070793 -
Annals of Laboratory Medicine May 2022Blood is lifesaving; however, it can neither be limitlessly acquired nor artificially produced. The supply and use of blood, as an invaluable biological commodity,... (Review)
Review
Blood is lifesaving; however, it can neither be limitlessly acquired nor artificially produced. The supply and use of blood, as an invaluable biological commodity, necessitate systematic and rational management under governmental guidance to ensure safe and reliable transfusions. Despite Korea's blood donation rate of 5.04%, which is higher than the 3.15% in high-income countries as reported by the WHO, the demand for blood exceeds the availability. This is due to the birthrate decline, dearth of young donors, and growing and aging recipient population. This review outlines the Korean blood management system, with a focus on blood service data from 2020, with the aim to delineate the current state of Korea's blood management system and the policies established to address the imminent blood shortage. Each policy is described in detail to provide helpful information for blood management services in other countries.
Topics: Blood Banks; Humans; Republic of Korea
PubMed: 34907100
DOI: 10.3343/alm.2022.42.3.306 -
Journal of Medicine and Life Jun 2022Cord blood is a rich source of hematopoietic stem cells used to treat many diseases of blood origin. Thus, storage banks were created to store and provide umbilical cord... (Review)
Review
Cord blood is a rich source of hematopoietic stem cells used to treat many diseases of blood origin. Thus, storage banks were created to store and provide umbilical cord cells. With the development of diagnostic and therapeutic technologies and techniques in medicine, ethical issues have also become more widespread and complex. After the creation of the cord blood banks, efforts were made to address the ethical issues associated with such banks. The present study attempts to identify the ethical challenges in these banks in the published studies. Databases including PubMed, Scopus, Web of Science (WOS), Embase, Proquest, and Google Scholar were searched from January 1996 to January 2021. Then, the ethical challenges of the cord blood bank were extracted from the results section using thematic content analysis. 22 studies were selected based on inclusion and exclusion criteria. The ethical challenges raised in the studies included private or public ownership of the bank, fair access to banking services, informed and voluntary consent, failure to provide sufficient information to individuals about the process, confidentiality of user's information, conflict of interest of bank founders (who are commonly doctors). The findings of this study indicated that there are serious ethical concerns regarding umbilical cord blood banks. Responding clearly to these ethical challenges calls for the attention of policymakers and medical ethics professionals; this will require a clear statement of the various aspects of these banks for society.
Topics: Blood Banks; Fetal Blood; Humans; Ownership
PubMed: 35928362
DOI: 10.25122/jml-2021-0162 -
Clinics in Laboratory Medicine Dec 2020SARS-CoV-2 (also known as COVID-19) has been an unprecedented challenge in many parts of the medical field with blood banking being no exception. COVID-19 has had a... (Review)
Review
SARS-CoV-2 (also known as COVID-19) has been an unprecedented challenge in many parts of the medical field with blood banking being no exception. COVID-19 has had a distinctly negative effect on our blood collection nationwide forcing blood banks, blood centers, and the US government to adopt new policies to adapt to a decreased blood supply as well as to protect our donors from COVID-19. These policies can be seen distinctly in patient blood management and blood bank operations. We are also faced with developing policies and procedures for a nontraditional therapy, convalescent plasma; its efficacy and safety is still not completely elucidated as of yet.
Topics: Betacoronavirus; Blood Banks; Blood Donors; Blood Safety; Blood Transfusion; COVID-19; Coronavirus Infections; Humans; Infection Control; Pandemics; Pneumonia, Viral; Policy Making; SARS-CoV-2; Transfusion Medicine; Blood Banking
PubMed: 33121624
DOI: 10.1016/j.cll.2020.08.013 -
Turkish Journal of Haematology :... Feb 2022Hematologists often encounter transfusion problems, one of which is crossmatch incompatibility. In many countries, transfusion medicine is not a recognized specialty,... (Review)
Review
Hematologists often encounter transfusion problems, one of which is crossmatch incompatibility. In many countries, transfusion medicine is not a recognized specialty, there are no reference immunohematology laboratories, and most blood banks can only perform “type and screen” and crossmatch analyses. Therefore, hematologists should have basic knowledge about blood banking procedures and how to use them. This review aims to provide hematologists who do not have access to advanced blood bank laboratories some practical tips for handling problems in pretransfusion testing.
Topics: Blood Banks; Blood Grouping and Crossmatching; Blood Transfusion; Humans; Transfusion Medicine
PubMed: 34886658
DOI: 10.4274/tjh.galenos.2021.2021.0544