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Frontiers in Endocrinology 2023Previous studies have shown that there is a correlation between diseases of the thyroid gland and mental illnesses; however, any causal relationship between them remains...
BACKGROUND
Previous studies have shown that there is a correlation between diseases of the thyroid gland and mental illnesses; however, any causal relationship between them remains unclear. This study aimed to evaluate the causal relationship between borderline personality disorder and four thyroid diseases.
METHODS
The causal relationship was inferred using double-sample Mendelian randomization analysis of appropriate instrumental variables from genome-wide association studies. We calculated the estimated value of the effect using various statistical methods.
RESULTS
Borderline personality disorder was a risk factor for non-toxic single thyroid nodules with each increase in standard deviation increasing the risk of a non-toxic single thyroid nodule by 1.13 times (odds ratio = 1.131; 95% confidence interval, 1.006-1.270; P=0.039). There was no evidence of a correlation between borderline personality disorder and hyperthyroidism/thyrotoxicosis, hypothyroidism, and autoimmune thyroiditis.
CONCLUSION
This study showed that there is a positive causal correlation between borderline personality disorder and non-toxic single thyroid nodules but not with other thyroid diseases. This means that thyroid status should be monitored in patients with borderline personality disorder. However, the possibility of a causal relationship between other mental illnesses and thyroid diseases requires further research.
Topics: Humans; Borderline Personality Disorder; Genome-Wide Association Study; Mendelian Randomization Analysis; Thyroid Nodule; Goiter
PubMed: 37854187
DOI: 10.3389/fendo.2023.1259520 -
Australian Prescriber Apr 2016Accurate diagnosis is fundamental to effective management of borderline personality disorder, but many patients remain undetected. The first-line management for... (Review)
Review
Accurate diagnosis is fundamental to effective management of borderline personality disorder, but many patients remain undetected. The first-line management for borderline personality disorder is psychosocial treatment, not drugs. There are major prescribing hazards including polypharmacy, overdose and misuse. Drug treatment might be warranted for patients who have a co-occurring mental disorder such as major depression. If a drug is prescribed for borderline personality disorder, it should only be as an adjunct to psychosocial treatment. There should be clear and collaborative goals that are regularly reviewed with the patient. Use single drugs prescribed in limited quantities for a limited time. Stop drugs that are ineffective.
PubMed: 27340322
DOI: 10.18773/austprescr.2016.019 -
Facial Plastic Surgery Clinics of North... Nov 2020Body dysmorphic disorder and borderline personality disorder are common in esthetic practices and occur in up to 15% of patients. Operating on these patients may not... (Review)
Review
Body dysmorphic disorder and borderline personality disorder are common in esthetic practices and occur in up to 15% of patients. Operating on these patients may not only lead to dissatisfaction but may also worsen their premorbid condition and can induce negative behavior toward the practice. Preventing surgery and referring patients for cognitive therapy is essential. An adequate understanding of these conditions and the available screening tools is indispensable for all esthetic practitioners. Unrealistic emotional attribution to a facial shape, multiple procedures, a near-normal nose at the outset, childhood trauma, multiple comorbid mental conditions, and social dysfunction are red-flags to consider.
Topics: Body Dysmorphic Disorders; Borderline Personality Disorder; Child; Child Abuse; Cosmetic Techniques; Humans; Patient Satisfaction; Rhinoplasty
PubMed: 33010863
DOI: 10.1016/j.fsc.2020.06.003 -
Psychopathology 2022Most articles and theories about borderline personality disorder (BPD), either in the psychoanalytical field or the cognitivist one, explicitly or implicitly inscribe... (Review)
Review
Most articles and theories about borderline personality disorder (BPD), either in the psychoanalytical field or the cognitivist one, explicitly or implicitly inscribe themselves in a topographical framework that either carry a fundamental representational a priori or give prominence to causal explanations. Less is written about the phenomenological everyday life-world of borderline people. This article aims to contribute to the description of such a world. Drawing upon clinical sequences that give prominence to the first-person perspective, we will analyse the experience of some typical "symptoms" of BPD in a phenomenological and topological way. We will be led to conclude that the borderline stimmung seems to display the following characteristics: a pervading immediacy of lived experience, a territorialization that tends towards ubiquity, a certain difficulty to deal with the unity and difference poles, a quite horizontal concern with ecstasy and elation, and a waning of reflexivity in the lived space.
Topics: Affect; Borderline Personality Disorder; Humans
PubMed: 35114681
DOI: 10.1159/000521182 -
Obstetrics & Gynecology Science May 2015Epithelial borderline ovarian tumors (BOT) are distinctive from benign tumors and carcinoma. They occur in younger women more often than carcinoma, and there is some... (Review)
Review
Epithelial borderline ovarian tumors (BOT) are distinctive from benign tumors and carcinoma. They occur in younger women more often than carcinoma, and there is some difficulty making correct diagnosis of BOT. Two subtypes of BOT, serous and mucinous borderline tumor have different characteristics and very different clinical behavior. Serous borderline tumor (SBT) with micropapillary pattern shows more incidence of extra ovarian disease and often coexists with invasive implant. SBT with micropapillary pattern in advanced stage has showed a worse prognosis than typical SBT. Huge mucinous borderline tumors have histologic heterogeneity, and the accuracy of frozen section diagnosis is relatively low. Extensive sampling is required to reach a correct pathological diagnosis. Mucinous adenoma (intestinal type) also runs the risk of recurrence after cystectomy, or intraoperative rupture of cyst. Laparoscopic procedure for BOT has not increased the risk of recurrence. Fertility preserving procedures are generally accepted, except in advanced stage SBT with invasive implants. Only cystectomy shows a significant risk of recurrence. Re-staging surgery and full staging surgery is not necessary for all BOT. We should not attempt to treat them uniformly, by the single diagnosis of "borderline tumor". It depends on histologic type. Close communication with the pathologist is necessary to gain more detail and ask more pathological samples in order to make the optimal treatment strategy for each individual patients.
PubMed: 26023666
DOI: 10.5468/ogs.2015.58.3.183 -
Journal of Clinical Medicine Aug 2022Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies in the United States. Improvements in imaging have permitted the categorization of... (Review)
Review
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies in the United States. Improvements in imaging have permitted the categorization of patients according to radiologic involvement of surrounding vasculature, i.e., upfront resectable, borderline resectable, and locally advanced disease, and this, in turn, has influenced the sequence of chemotherapy, surgery, and radiation therapy. Though surgical resection remains the only curative treatment option, recent studies have shown improved overall survival with neoadjuvant chemotherapy, especially among patients with borderline resectable/locally advanced disease. The role of radiologic imaging after neoadjuvant therapy and the potential benefit of adjuvant therapy for borderline resectable and locally advanced disease remain areas of ongoing investigation. The advances made in the treatment of patients with borderline resectable/locally advanced disease are promising, yet disparities in access to cancer care persist. This review highlights the significant advances that have been made in the treatment of borderline resectable and locally advanced PDAC, while also calling attention to the remaining challenges.
PubMed: 36013111
DOI: 10.3390/jcm11164866 -
World Journal of Gastrointestinal... Aug 2021Surgical resection for colorectal liver metastases (CRLM) may offer the best opportunity to improve prognosis. However, only about 20% of CRLM cases are indicated for... (Review)
Review
Surgical resection for colorectal liver metastases (CRLM) may offer the best opportunity to improve prognosis. However, only about 20% of CRLM cases are indicated for resection at the time of diagnosis (initially resectable), and the remaining cases are treated as unresectable (initially unresectable). Thanks to recent remarkable developments in chemotherapy, interventional radiology, and surgical techniques, the resectability of CRLM is expanding. However, some metastases are technically resectable but oncologically questionable for upfront surgery. In pancreatic cancer, such cases are categorized as "borderline resectable", and their definition and treatment strategies are explicit. However, in CRLM, although various poor prognosis factors have been identified in previous reports, no clear definition or treatment strategy for borderline resectable has yet been established. Since the efficacy of hepatectomy for CRLM was reported in the 1970s, multidisciplinary treatment for unresectable cases has improved resectability and prognosis, and clarifying the definition and treatment strategy of borderline resectable CRLM should yield further improvement in prognosis. This review outlines the present status and the future perspective for borderline resectable CRLM, based on previous studies.
PubMed: 34512899
DOI: 10.4240/wjgs.v13.i8.756 -
Current Psychiatry Reports Jan 2013We review recent gene-environment studies relevant to borderline personality disorder, including those focusing on impulsivity, emotion sensitivity, suicidal behavior,... (Review)
Review
We review recent gene-environment studies relevant to borderline personality disorder, including those focusing on impulsivity, emotion sensitivity, suicidal behavior, aggression and anger, and the borderline personality phenotype itself. Almost all the studies reviewed suffered from a number of methodological and statistical problems, limiting the conclusions that currently can be drawn. The best evidence to date supports a gene-environment correlation (rGE) model for borderline personality traits and a range of adverse life events, indicating that those at risk for BPD are also at increased risk for exposure to environments that may trigger BPD. We provide suggestions regarding future research on GxE interaction and rGE effects in borderline personality.
Topics: Aggression; Borderline Personality Disorder; Emotions; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Impulsive Behavior; Phenotype; Risk Factors; Suicidal Ideation
PubMed: 23250817
DOI: 10.1007/s11920-012-0336-1 -
Heliyon Aug 2022Spousal violence in Pakistan is under researched but still not considered as a public health problem. The current study is intended to analyze the association between...
OBJECTIVE
Spousal violence in Pakistan is under researched but still not considered as a public health problem. The current study is intended to analyze the association between multiple measures of impulsivity, impulsive aggression, and borderline personality feature among violent spouses as well as to find out the moderating role of impulsive aggression between spousal violence and borderline personality features.
METHODS
A cross-sectional survey research design was used for conducting the research. The sample of 300 spouses, experiencing intimate partner relationships, was taken from different cities of the Hazara division through purposive sampling.
RESULTS
Present study demonstrated a significant positive correlation of spousal violence with impulsivity (r = .708∗∗, P < .001), impulsive aggression (r = .176∗∗, P < .001), and borderline personality features (r = .605∗∗, P < .001), while impulsivity was negatively correlated with impulsive aggression (r = -.018, P < .01). Impulsive aggression moderates the relationship between spousal violence and borderline personality features. The results showed that male and female spouses were found equally impulsive and impulsively aggressive. Likewise, impulsivity, impulsive aggression, and borderline personality features were found significant predictors of violence F = (3, 296) = 106. 67, P < .001.
CONCLUSION
Current research offers some important insights and consequences for physicians and practitioners who interact with individuals who have experienced violence. These results have significant therapeutic implications for the treatment of violent couples.
PubMed: 36033274
DOI: 10.1016/j.heliyon.2022.e10135 -
Journal of Psychiatric Research Aug 2017Borderline Personality (BPD) and Bipolar (BP) disorders stimulate an academic debate between their distinction and the inclusion of Borderline in the Bipolar spectrum....
Borderline Personality (BPD) and Bipolar (BP) disorders stimulate an academic debate between their distinction and the inclusion of Borderline in the Bipolar spectrum. Opponents to this inclusion attribute the important differences and possible diagnostic incomprehension to overlapping symptoms. We tested 248 Borderline and 113 Bipolar patients, consecutively admitted to the Psychiatric Unit, through DSM-IV Axis I and II Disorders (SCID-I/II), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Young Mania Rating Scale (YMRS) and Borderline Personality Disorder Severity Index-IV (BPDSI-IV). All the tests statistically discriminated the disorders (p < 0.0001). Overlapping symptoms resulted significantly different (impulsivity = 5.32 in BPD vs 1.55 in BP, p < 0.0001; emotional instability = 7.11 in BPD vs 0.55 in BP, p < 0.0001) and the range of their scores gives the opportunity for an even more precise discrimination. Distinctive traits (e.g. irritability or sexual arousal) are also discussed in order to try to qualify the core of these disorders to a higher degree. Comorbidity proves to be extremely small (3.6%). However, Borderline patients with manic features offer a privileged point of view for a deeper analysis. This allows for the possibility of a more precise examination of the nature and load of each symptom. Borderline Personality and Bipolar Disorders can be distinguished with high precision using common and time-sparing tests. The importance of discriminating these clinical features may benefit from this evidence.
Topics: Analysis of Variance; Bipolar Disorder; Borderline Personality Disorder; Female; Humans; Male; Psychiatric Status Rating Scales
PubMed: 28327444
DOI: 10.1016/j.jpsychires.2017.03.006