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European Review For Medical and... Apr 2023Hyaluronic acid has been efficient in ameliorating and supporting recovery in both chronic and acute lesions. The aim of this study was to assess the effectiveness of...
OBJECTIVE
Hyaluronic acid has been efficient in ameliorating and supporting recovery in both chronic and acute lesions. The aim of this study was to assess the effectiveness of hyaluronic acid-based cream and gauze pads in cutaneous wounds.
PATIENTS AND METHODS
This retrospective and prospective study examines the use of a 0.2% hyaluronic acid cream or gauze-pads application (Connettivina Bio®). 85 patients participated in the study and were affected by wounds of different etiologies, comprising superficial trauma wounds (20), surgical sutures (15), first- and second-degree burns (15), dermabrasions (30) and ulcers of different etiologies (5). We analyzed the healing process in terms of progression and wound quality. Moreover, we performed biopsies (not on all patients) to evaluate the grade of re-epithelialization.
RESULTS
We observed a reduction in the mean surface area of the wounds, precisely 456 mm2 at baseline to 147 mm2 after six weeks with an average 86% [corrected] decrease in the wound surface area. No fibrin tissue was observed, and a small amount of exudate was noted in 10% [corrected] of wounds. Hyaluronic acid cream and gauze-pads-based treatments were well tolerated by patients. All groups showed a decrease of inflammation with a progressive increase of collagen fibers and granulation tissue.
CONCLUSIONS
The treatment with hyaluronic acid 0.2% yielded remarkable outcomes in the re-epithelialization of superficial wounds and provided favorable recovery and tolerance for patients.
Topics: Humans; Re-Epithelialization; Hyaluronic Acid; Prospective Studies; Retrospective Studies; Wound Healing
PubMed: 37129334
DOI: 10.26355/eurrev_202304_31320 -
Heliyon Jul 2021Acute injuries, such as surgical and traumatic, heal normally in an organized and rapid manner. Studies point to the healing activity of hyaluronic acid in all phases of...
Acute injuries, such as surgical and traumatic, heal normally in an organized and rapid manner. Studies point to the healing activity of hyaluronic acid in all phases of healing. The aim was to evaluate the effectiveness of hyaluronic acid in skin abrasions on the dorsum of rats to compare to usual products on the market. Seventy-two Wistar rats were subjected to excoriation of approximately 2.0 cm on the back by dermabrasion. According to the treatment, 3 groups were established: saline, chlorhexidine digluconate and 0.2% hyaluronic acid for 14 days. Animals were photographed on the 2, 7, 10 and 14 postinjury days, and the index of healing of the abrasions was calculated. Biochemically, myeloperoxidase measurements of skin biopsies in addition to histological studies to assess the crust and epidermal layers were performed. The group treated with hyaluronic acid showed better re-epithelialization from the other groups (p < 0.05) on the 7 and 10 days. For the thickness of the crust, the hyaluronic acid group presented thinner crust than other groups on the 10 and 14 days (p < 0.05), but in the epidermis, no difference was observed between the groups studied. All groups showed an increase in myeloperoxidase enzyme on the 2 day, but a decreasing on the 7 day. On the 10 day, there was a difference in the hyaluronic acid group compared to the other groups (p < 0.05). The application of 0.2% hyaluronic acid significantly accelerated the re-epithelialization of skin abrasions compared to saline and chlorhexidine digluconate.
PubMed: 34345742
DOI: 10.1016/j.heliyon.2021.e07572 -
Eplasty 2022
PubMed: 35706823
DOI: No ID Found -
British Medical Journal Aug 1974
Topics: Abdomen; Breast; Buttocks; Chin; Cicatrix; Dermabrasion; Ear; Eyelids; Face; Female; Humans; Male; Methods; Neck; Rhinoplasty; Surgery, Plastic; Thigh; Wound Healing
PubMed: 4412664
DOI: 10.1136/bmj.3.5930.566 -
Dermatology Reports Sep 2023Hailey-Hailey disease (HHD), or familial benign pemphigus, is a rare genetic condition characterized by recurrent blisters and erosions with a predilection for...
Hailey-Hailey disease (HHD), or familial benign pemphigus, is a rare genetic condition characterized by recurrent blisters and erosions with a predilection for intertriginous areas. There is no specific treatment for HHD. Topical and systemic treatments tend to provide temporary remission. Alternative treatment (surgical interventions such as dermabrasion, excision, and laser) has been shown to prolong remission. Considering the risk of complications associated with surgical modalities, laser is often preferred as an alternative for patients failing to respond to first-line therapies. We report a case of recalcitrant HHD successfully treated with a fractional ablative CO laser procedure (wavelength of 10600 nm, power of 7-10 W, 2-3 passes) on a 35-year-old female. The patient has a 7-year history of therapy-resistant HHD. A 2-month followup showed substantially resolved lesions, with mild erythema and post-inflammatory hyperpigmentation in treated areas.
PubMed: 37860724
DOI: 10.4081/dr.2023.9658 -
International Journal of Surgery Case... 2020Rhinophyma is benign hypertrophic thickening of the skin and edema of the nasal pyramid. The affected tissue enlarges slowly before reaching its permanent size. The...
INTRODUCTION
Rhinophyma is benign hypertrophic thickening of the skin and edema of the nasal pyramid. The affected tissue enlarges slowly before reaching its permanent size. The lobulated skin surface with hundreds of pores can become cosmetically embarrassing and cause significant psychosocial stress, anxiety, and depression for patients. In addition, extensive alar thickening can obstruct the external nasal valves making treatment necessary to alleviate respiratory issues. No consensus has been reached regarding management of rhinophyma and many surgeons follow the "to each his own technique" mindset. Our objective was to present a case report to support the use of electrocautery and dermabrasion as the mainstay of treatment.
PRESENTATION OF CASE
Here we describe the case of a 62-year-old Caucasian male with a long-standing history of acne rosacea who developed severe rhinophyma overtime which lead to nasal obstruction and major cosmetic deformity. Electrocautery and dermabrasion in the operating room were utilized to obtain an outstanding cosmetic result and respiratory function improvement. Loop and Colorado cautery tips were used with cutting current to remove the hypertrophic skin and create a smooth contour. The patient tolerated the procedure well without any complications. The patient's skin was scab-free with normal pigmentation by four weeks post-op. He was satisfied with the cosmetic outcome and reported substantial improvement in his breathing.
DISCUSSION
There have been several case reports published which describe using different surgical methods to treat rhinophyma including lasers, electrocautery dermabrasion, surgical blade, cryosurgery, and radio excision. The main limitations of laser therapy are imprecise tissue removal, risk of scarring, dyspigmentation, and bleeding. Other therapies such as surgical excision and skin grafts may require multiple procedures before obtaining a satisfactory cosmetic outcome.
CONCLUSION
This case report supports electrocautery dermabrasion as the mainstay of treatment as it is a management technique which allows for smooth contouring, efficient hemostasis, more control in the operating room, and does not require multiple procedures.
PubMed: 32698277
DOI: 10.1016/j.ijscr.2020.06.039 -
Iranian Journal of Medical Sciences May 2016Freckles are numerous pigmented spots of the skin, mainly confined to the face, even arms and back. Although freckles are light-brown macules, most frequently observed...
BACKGROUND
Freckles are numerous pigmented spots of the skin, mainly confined to the face, even arms and back. Although freckles are light-brown macules, most frequently observed in individuals with red or blond hair, they are common to Asian people too. Freckles increase in number, size, and depth of pigmentation during the summer months. Histologically, freckles show increased production of melanin pigment by a normal number of melanocytes. Freckles commonly stop spreading before adolescence and last for life, but could sometimes be subtle in adulthood. Treatments are often requested for cosmetic purposes. Before the advent of lasers, treatment modalities for pigmentary disorders included surgical excision, dermabrasion, chemical bleaching, and peeling. These treatments may lead to unwanted side effects of potential scarring or undesired pigmentation changes. In Iranian traditional medicine (ITM), freckles have been known as well. "Namash" was the term used by ITM scholars to indicate freckles. There is a wide range of plants, which were prescribed by Iranian physicians for the treatment of freckles. The purpose of this study is to find the most frequent useful herbs for freckles as mentioned in ITM references.
METHODS
Seven ITM references were studied for anti-freckles medicines. The references were Canon of Medicine (Avicenna), Alhavi (Razes) Tuhfat ul-Momineen (Momen tonekaboni), Makhzan-ul-Adwiah (Aghili), Ikhtiyarat Badi'i (Ansari), Al-abnia An-Haghyegh el-advia (Heravi), and al-jāmi li-mufradāt al-adwiyawa al-aghdhiya (Ibn al-Baitar). Moreover, plants were ordered according to their repetition in the references. Afterwards, traditional names of the selected plants were matched with the scientific names using botanical text references.
RESULTS
This study demonstrated that Myristica fragrans Houtt, Cicer arietema L., Eruca sativa Lam., Lilium candidium L., Amygdalus communis L., Arum italicum L. were the most frequent herbs mentioned in ITM references for the treatment of freckles.
CONCLUSION
Herbs mentioned in this article could be appropriate candidates for future studies in the field of freckles treatment.
PubMed: 27840488
DOI: No ID Found -
Clinical, Cosmetic and Investigational... 2023An in-office diamond tip microdermabrasion device (DG) was designed to simultaneously exfoliate, extract, and infuse topical cosmetic serums into the skin to improve its...
Combining Diamond-Tip Dermabrasion Treatments and Topical Skincare in Participants with Dry, Hyperpigmented, Photodamaged or Acne-Prone/Oily Facial Skin: A Clinical Usage Study.
PURPOSE
An in-office diamond tip microdermabrasion device (DG) was designed to simultaneously exfoliate, extract, and infuse topical cosmetic serums into the skin to improve its appearance. Combining in-office procedures with take-home skincare may enhance treatment outcomes. This study aimed to assess the efficacy of a novel combination of DG treatments with a take-home cosmetic skincare regimen (DGR) to address facial dryness, hyperpigmentation, photodamage, or acne-prone/oily skin.
PATIENTS AND METHODS
In this 12-week, open-label, single-center study, participants were assigned to 1 of 4 groups according to skin presentation: dry, hyperpigmented, photodamaged, or acne-prone/oily. All participants received 6 bi-weekly DG treatments with tailored DGR topical products. During the DG treatment, the dry, hyperpigmented, photodamaged, and acne-prone/oily groups received hydrating, brightening, antioxidant, and pore-clarifying serums, respectively. Study endpoints included investigator grading, standardized photography, and participant questionnaires.
RESULTS
Sixteen participants aged 22 to 70 years with Fitzpatrick Skin Types I-V completed the study. Immediately after the first DG treatment, significant improvements in dryness, radiance, texture, photodamage, and fine lines were achieved (P<0.01). At 72 hours, significant improvements were maintained in all these parameters except fine lines (P<0.05). The DG and DGR combination provided significant long-term improvements at week 12 compared to baseline for dryness, radiance, texture, hyperpigmentation, photodamage, skin tone unevenness, and periocular/perioral fine lines (P<0.05).
CONCLUSION
The combination of DG and DGR showed significant immediate and long-term improvements in skin appearance. These results show that the DG and DGR combination is a well-tolerated and effective intervention to enhance different aspects of facial skin quality.
PubMed: 37780689
DOI: 10.2147/CCID.S423688 -
Advances in Skin & Wound Care Jul 2023Although dermabrasion is widely used to treat various skin diseases and for scar repair, relatively few reports have described its use with burn wounds. As a blunt...
Although dermabrasion is widely used to treat various skin diseases and for scar repair, relatively few reports have described its use with burn wounds. As a blunt debridement, eschar dermabrasion has unique advantages. For patients with deep burns, the boundary between active tissue and inactive tissue is unclear. With eschar dermabrasion, necrotic tissue can be removed to the greatest extent with minimal damage. Early use can help patients skip the scab-dissolving period, decrease local and systemic inflammation, reduce postoperative scarring, and significantly reduce the difficulty of early wound care. As a result, the patient's hospitalization costs and pain during treatment are both reduced, and thanks to less scarring, the patient is more likely to engage in social activities and has an improved quality of life.
Topics: Humans; Cicatrix; Wound Healing; Dermabrasion; Quality of Life; Skin Transplantation; Skin Diseases; Burns
PubMed: 37338951
DOI: 10.1097/01.ASW.0000936004.14772.21 -
Clinical, Cosmetic and Investigational... 2020Rhinophyma is a cosmetic disorder that causes emotional distress if the symptoms are extensive or obvious enough. Treatment options range from topical antibiotics or...
INTRODUCTION
Rhinophyma is a cosmetic disorder that causes emotional distress if the symptoms are extensive or obvious enough. Treatment options range from topical antibiotics or isotretinoin, surgical resection, cryosurgery, electrocautery, dermabrasion and more recently laser therapy. With the limitations of surgical techniques, lasers gained popularity for treating rhinophyma. However, laser ablation is invasive and can lead to side effects and prolonged downtime. Fractional photothermolysis (FP) was introduced to overcome the limitations posed by conventional ablative lasers. To the best of our knowledge, there are no previous studies to evaluate the use of Er:YAG in an ablative mode with a fractional handpiece for the treatment of rhinophyma.
AIM OF THE WORK
The goal of this study was to evaluate the efficacy and safety of fractional ablative 2940 nm Er:YAG laser for the treatment of mild to moderate rhinophyma.
PATIENTS AND METHODS
Sixteen patients having mild to moderate rhinophyma were treated with fractional ablative 2940 nm Er:YAG laser. All patients received 4 laser treatments and were followed up over the following 3 months. An additional follow-up appointment 6 months after the last session was arranged to detect any signs of recurrence.
OUTCOME MEASURES
Patient questionnaire was used to evaluate patient subjective satisfaction. Objective evaluation was performed by a blind assessment of clinical photographs that were taken before and 3 months after the final treatment by two independent blinded evaluators.
RESULTS
Patient questionnaire taken 3 months after last treatment revealed that 8 patients (50%) were "very satisfied", 4 patients (25%) were satisfied, and 4 patients (25%) were somewhat satisfied. None of the patients assessed their results as not satisfying.
CONCLUSION
In conclusion, the use of patterned ablative Er:YAG laser with a PS01 handpiece and parameters used in this study comprise an effective tool for treatment of mild to moderate rhinophyma with rapid postoperative recovery compared with conventional surgical procedures and other ablative lasers.
PubMed: 33335414
DOI: 10.2147/CCID.S286847